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IBECS, IME

Métricas

  • SCImago Journal Rank (SJR):0,11
  • Source Normalized Impact per Paper (SNIP):0,119
doi: 10.1016/S0304-5013(01)75645-2
Caracterización preoperatoria de las tumoraciones de ovario mediante ecografía, Doppler y determinación sérica de CA125. Estudio comparativo
Preoperative characterization of ovarian tumors by Doppler ultrasonography and serum CA125 determination
M.J. Canto, , J.M. Martínez, B. Puerto, L.M. Puig-Tintoré, J.A. Vanrell
Institut Clínic de Ginecologia, Obstetrícia i Neonatologia (ICGON). Hospital Clínic. Barcelona
J. Ojuel
* Unitat de Bioestadística. Universitat de Barcelona
Recibido 22 diciembre 2000, Aceptado 21 marzo 2001
Resumen
Objetivo

Determinar la capacidad diagnóstica de la ecografía, el Doppler-color y pulsado, y la determinación sérica de CA125 en el diagnóstico diferencial de las tumoraciones anexiales.

Material Y Métodos

Un total de 126 pacientes con una tumoración anexial fueron evaluadas mediante ecografía, Doppler-color y pulsado y determinación sérica de CA125 de forma previa a la cirugía. Se calcula la capacidad de cada parámetro en términos de sensibilidad, especificidad, valores predictivos positivo y negativo, precisión global y razón de riesgo.

Resultados

Un total de 98 (77,7%) tumores fueron benignos y 28 (22,2%) malignos. Los tumores malignos presentaron, de forma significativa, mayor volumen, paredes y tabiques más gruesos, mayor frecuencia de partes sólidas y de ascitis, vascularización más intensa, distribución central de los vasos y valores superiores de CA125 que los tumores benignos. El tipo ecográfico más frecuentemente asociado a malignidad fue el quiste sólido multilocular, siendo la presencia de partes sólidas la variable con mayor potencia discriminatoria.

Conclusiones

La información que aporta el estudio ecográfico convencional es superior a la que aporta el estudio de la vascularización del tumor y el marcador tumoral CA125.

Abstract
Objective

The aim of our study is to evaluate the usefulness of ultrasound, color and pulsed Doppler and serum CA125 in the prediction of malignancy in ovarian masses.

Material And Methods

Over a one year period, 126 women diagnosed of an adnexal mass underwent a complete ultrasound color and pulsed Doppler examination and a serum determination of CA125 previously to surgical procedure. Results were correlated with histological findings. Several ultrasound and Doppler parameters were assessed by means of standard statistical analysis in terms of sensitivity, specificity, positive and negative predictive values, and odds ratio.

Results

Twenty-eight (22.2%) ovarian cancers were diagnosed. Malignant tumors showed higher levels of CA125 and were of greater volume, thicker walls and septae, with solid parts and ascites, and more abundant, and centrally located pattern of vascularity. The multicystic with solid parts type was the one most frequently was associated with malignancy, being the presence of solid parts the most powerful discrimatory variable.

Conclusions

In the preoperative evaluation of an adnexal mass, conventional ultrasound examination is more effective than vascularity evaluation by means of Doppler or serum CA125, in order to predict malignancy.

Palabras clave
Tumor ovario, Ecografía, Doppler, CA125
Keywords
Ovarian tumor, Ultrasound, Doppler, CA125
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Correspondencia: Ctra. Sant Cugat, 11–15, 2.° 1.a.08035 Barcelona.
Copyright © 2001. Sociedad Española de Ginecología y Obstetricia