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doi: 10.1016/j.genhosppsych.2010.10.009

Potentiating effect of fluphenazine decanoate and risperidone on development of neuroleptic malignant syndrome


We present the case of a woman with paranoid schizophrenia who was receiving oral risperidone. She developed neuroleptic malignant syndrome (NMS) following the addition of depot fluphenazine for the treatment of refractory delusions. NMS subsided and psychotic features were controlled after both antipsychotics were discontinued and the patient was treated instead with olanzapine.