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FI 2015

1,530
© Thomson Reuters, Journal Citation Reports, 2015

Indexada en:

Index Current Contents/Clinical Medicine, JCR, SCI-Expanded, Index Medicus/Medline, Excerpta Medica/EMBASE, IBECS, IME, CANCERLIT, SCOPUS

Métricas

  • Factor de Impacto: 1,530(2015)
  • 5-años Factor de Impacto: 1,710
  • SCImago Journal Rank (SJR):0,43
  • Source Normalized Impact per Paper (SNIP):0,653
doi: 10.1157/13089695
Formación médica continuada
Hepatitis por virus del grupo herpes
Hepatitis due to herpes group viruses
José M. Cisneros-Herreros, , Marta Herrero-Romero
Servicio de Enfermedades Infecciosas. Hospital Universitario Virgen del Rocío. Sevilla. España
Recibido 27 marzo 2006, Aceptado 29 marzo 2006
Resumen

La primoinfección por los virus herpes simple (VHS), varicela-zóster (VVZ), citomegalovirus (CMV), herpesvirus humano 6 y virus de Epstein-Barr (VEB) ocasiona hepatitis generalmente leve y autolimitada en pacientes inmunocompetentes. La primoinfección por el VHS en neonatos y en embarazadas, y también por el VVZ en pacientes hematológicos y receptores de trasplante de progenitores hematopoyéticos puede causar una hepatitis fulminante sin las lesiones cutáneas características. En los receptores de trasplante hepático, la hepatitis es la expresión más común de la infección por CMV y sus manifestaciones son indistinguibles del rechazo agudo. La hepatitis persistente es una manifestación del síndrome de infección crónica activa por el VEB. La hepatitis fulminante por virus herpes tiene tratamiento eficaz si se inicia precozmente, para ello es necesario tener un alto grado de sospecha clínica e incluir los virus herpes en el diagnóstico diferencial de este síndrome.

Resumen

In immunocompetent patients, primary infection by herpes simplex virus (HSV), varicella-zoster virus (VZV), cytomegalovirus (CMV), human herpesvirus 6, and Epstein-Barr virus (EBV) generally produces mild, self-limited hepatitis. Primary infection by HSV in neonates and pregnant women, and infection by VZV in hematological and bone marrow recipients can cause fulminant hepatitis without characteristic skin lesions. In liver transplant recipients, hepatitis is the most common expression of CMV infection and the related symptoms are indistinguishable from those of acute rejection. Persistent hepatitis is a manifestation of the syndrome of active chronic infection by the EBV. Fulminating hepatitis due to herpes virus can be treated effectively if therapy is started early; hence, a high degree of clinical suspicion and inclusion of herpes virus in the differential diagnosis of this syndrome is necessary.

Palabras clave
Hepatitis, Virus herpes simple, Virus varicela-zóster, Citomegalovirus, Virus Epstein-Barr
Key words
Hepatitis, Herpes simplex virus, Varicellazoster virus, Cytomegalovirus, Epstein-Barr virus
El Texto completo solo esta disponible en PDF
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Correspondencia: Dr. J.M. Cisneros-Herreros. Servicio de Enfermedades Infecciosas. Hospital Universitario Virgen del Rocío. Avda. Manuel Siurot, s/n. 41013 Sevilla. España.
Copyright © 2006. Elsevier España S.L.