Información del artículo
Pseudopheochromocytoma is a rare entity that has recently been defined. It occurs in patients with a clinical diagnosis of pheochromocytoma but without the typical medullary tumor; instead, they have an adrenal cortical adenoma or carcinoma. We report a patient with hypertension, elevated catecholamine levels and radiologic findings suggestive of pheochromocytoma. Pathological study was conclusive for adrenocortical adenoma. We review the literature on pseudopheochromocytoma, the usefulness of immunohistochemical markers in the study of adrenal tumors and discuss the neuroendocrine differentiation of adrenal cortical tumors.
Palabras clave:
Feocromocitoma
Neoplasia cortical suprarrenal
Diferenciación neuroendocrina
Inmunohistoquímica
Key words:
Pheochromocytoma
Adrenal cortical neoplasm
Neuroendocrine differentiation
Immunohistochemistry
El seudofeocromocitoma es una rara entidad recientemente definida. Ocurre en pacientes con el diagnóstico clínico de feocromocitoma pero sin el típico tumor medular suprarrenal, en lugar del que suele encontrarse un adenoma o un adenocarcinoma cortical suprarrenal. Describimos a una paciente con hipertensión arterial, hipersecreción de catecolaminas y hallazgos radiológicos compatibles con feocromocitoma, cuyo examen anatomopatológico fue concluyente de adenoma cortical. Revisamos la bibliografía referente al seudofeocromocitoma, la utilidad de los marcadores inmunohistoquímicos empleados en el estudio histopatológico de los tumores suprarrenales y, finalmente, se discute la patogenia de la diferenciación neuroendocrina de los tumores corticales.
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