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doi: 10.1016/S1575-0922(04)74647-1
Homocisteína, metabolismo y determinantes higienicodietéticos
Homocysteine, Metabolism And Dietary Factors
D.A. De Luis, , N. Fernández, R. Aller
Servicio de Endocrinología y Nutrición. Unidad de Apoyo a la Investigación. Hospital Universitario Río Hortega. Instituto de Endocrinología y Nutrición. Facultad de Medicina. Valladolid. España
Recibido 08 julio 2003, Aceptado 17 noviembre 2003
Resumen

Homocysteine (Hcy) is a sulfur-containing amino acid with a free thiol group that is not found in dietary proteins but is exclusively produced as an intermediate product of methionine and cysteine metabolism. Therefore, the only source of this amino acid is methionine. Hcy concentration is secondary to complex interaction among multiple external and genetics factors and is modified by a series of physiological determinants such as age, sex, menopause, pregnancy and race. Genetic defects can also modify Hcy concentrations and 3 defects have been described: cystathionine-β-synthase deficiency (CBS), N5,N10- methylenetetrahydrofolate reductase deficiency (MTHFR) and methionine synthase deficiency (MS). Among the dietary factors that can influence Hcy concentrations are vitamin status, smoking and alcohol consumption, dietary protein intake, and exercise. The consumption of certain drugs, as well as manipulation of the sample obtained, can also influence Hcy levels.

All of these factors should be taken into account when determining Hcy concentrations.

Resumen

La homocisteína es un aminoácido azufrado caracterizado por la presencia de un grupo tiol libre, que no está presente en las proteínas de la dieta sino que se forma exclusivamente como producto intermediario en el metabolismo de la metionina a cisteína. Por tanto, la única fuente de homocisteína en el organismo es el aminoácido esencial metionina. La concentración de homocisteína total es producto de una compleja interacción entre múltiples factores genéticos y ambientales. En su concentración influyen una serie de determinantes fisiológicos, como la edad, el sexo, la menopausia, el embarazo y la raza. Los defectos genéticos también pueden influir en las concentraciones de homocisteína; existen 3 déficit descritos: deficiencia de cistationina-β-sintasa, deficiencia de la N5,N10-metilentetrahidrofolato reductasa y deficiencia de metionina sintasa. Dentro de los determinantes dietéticos que pueden influir en los valores de homocisteína podemos citar el estatus vitamínico, el consumo de alcohol y tabaco, el contenido de metionina de las proteínas de la dieta y el ejercicio. El consumo de determinados fármacos, así como la manipulación de la muestra obtenida, también puede influir en las concentraciones de este aminoácido.

Es necesario tener en cuenta todos estos determinantes higienicodietéticos a la hora de valorar una determinación aislada de homocisteína.

Palabras clave
Dieta, Homocisteína, Metabolismo
Key words
Diet, Homocysteine, Metabolism
El Texto completo solo esta disponible en PDF
Biblografía
1.
J.D. Finkelstein
Methionine metabolism in mammals
J Nutr Biochem, 1 (1990), pp. 228-237
2.
P.M. Ueland
Homocysteine species as components of plasma redox thiol status
Clin Chem, 41 (1995), pp. 340-342
3.
M.A. Mansoor,A.M. Svardal,J. Schneede,P.M. Ueland
Dynamic relation between reduced, oxidized, and protein-bound homocysteine and other thiol components in plasma during methionine loading in healthy men
Clin Chem, 38 (1992), pp. 1316-1321
4.
H. Refsum,S. Helland,P.M. Ueland
Radioenzymic determination of homocysteine in plasma and urine
Clin Chem, 31 (1985), pp. 624-628
5.
J.M. Mato,L. Alvarez,P. Ortiz,M.A. Pajares
S-Adenosylmethionine synthesis: molecular mechanism and clinical implications
Pharmacol Ther, 73 (1997), pp. 265-280
6.
S-S Kang,P.W.K. Wong,M.R. Malinow
Hyperhomocystein(e)mia as a risk factor for oclussive vascular disease
Ann Rev Nutr, 12 (1992), pp. 279-298
7.
O. Nygard,S.E. Vollset,H. Refsum,I. Stensvold,A. Tverdal,J.E. Nordrehaug
Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study
JAMA, 274 (1995), pp. 1526-1533
8.
F. Wollesen,L. Brattstrom,H. Refsum,P.M. Ueland,L. Berglund,C. Berne
Plasma total homocysteine and cysteine in relation to glomerular filtration rate in diabetes mellitus
Kidney Int, 55 (1999), pp. 1028-1035
9.
J.B. Ubbink
Should all elderly people receive folate supplements?
Drugs Aging, 13 (1998), pp. 415-420
10.
R. Carmel
Cobalamin, the stomach, and aging
Am J Clin Nutr, 66 (1997), pp. 750-759
11.
L. Brattstrom,A. Lindgren,B. Israelsson,A. Andersson,B. Hultberg
Homocysteine and cysteine: determinants of plasma levels in middle-aged and elderly subjects
J Intern Med, 236 (1994), pp. 633-641
12.
A. Andersson,A. Isaksson,B. Hultberg
Homocysteine export from erythrocytes and its implication from plasma sampling
Clin Chem, 38 (1992), pp. 1311-1315
13.
R. Carmel,R. Green,D.W. Jacobsen,K. Rasmussen,M. Florea,C. Azen
Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities
Am J Clin Nutr, 70 (1999), pp. 904-910
14.
J.B. Ubbink,W.J. Vermaak,A. Van der Merwe,P.J. Beckr
The effect of blood sample aging and food consumption on plasma total homocysteine levels
Clin Chem Acta, 207 (1992), pp. 119-128
15.
H. Refsum,P.M. Ueland,O. Nygard,S.E. Vollset
Homocysteine and cardiovascular disease
Annu Rev Med, 49 (1998), pp. 31-62
16.
M.J. Van der Moren
Homocysteine: influences of menopausal status and postmenopausal hormone replacement therapy
Neeth J Med, 52 (1998), pp. 44
17.
V. Mijatovic,C. Netelenbos,M.J. Van der Mooren,G.W. De Valk-de Roo,C. Jakobs,P. Kenemans
A randomized controlled study of the effects of 17-βÀ-estradiol-dydrogesterone on plasma homocysteine in posmenopausal women
Obstet Gynecol, 91 (1998), pp. 432-436
18.
R.A. Hegele,C. Tully,T.K. Young,P.W. Connelly
V677 mutation of methylenetetrahydrofolate reductase and cardiovascular disease in Canadian Inuit
Lancet, 349 (1997), pp. 1221-1222
19.
R.F. Franco,A.G. Araujo,J.F. Guerreiro,J. Elion,M.A. Zago
Analysis of the 677 Cš¨T mutation of the methylenetetrahydrofolate reductase gene in different ethnic groups
Thromb Haemost, 79 (1998), pp. 119-121
20.
M. Hiroyuki
Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as risk factor for coronary artery disease
Circulation, 95 (1997), pp. 2032-2036
21.
O. Nygard,H. Refsum,P.M. Ueland,S.E. Vollset
Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study
Am J Clin Nutr, 67 (1998), pp. 263-270
22.
J.B. Ubbink,A. Van der Merwe,R. Delport,R.H. Allen,S.P. Stabler,R. Riezler
The effect of a subnormal vitamin B6 status on homocysteine metabolism
J Clin Invest, 98 (1996), pp. 177-184
23.
C. Nagata,H. Shimizu,R. Takami,M. Hayashi,N. Takeda,K. Yasuda
Soy product intake is inversely associated with serum homocysteine level in premmenopausal Japanese women
J Nutr, 133 (2003), pp. 797-800
24.
I.M. Graham,L.E. Daly,H.M. Refsum,K. Robinson,L.E. Brattstrom,P.M. Ueland
Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project
JAMA, 277 (1997), pp. 1775-1781
25.
V. Ganji,M.R. Kafai
Third National Health and Nutrition Examination Survey. Demographic, helath, lifestyle, and blood vitamin determinants of serum total homocysteine concentrations in the third National Helth and Nutrition Examination Survey, 1988-1994
Am J Clin Nutr, 77 (2003), pp. 826-833
26.
A.B. Guttmorsen,J. Schneede,T. Fiskerstrand
Plasma concentrations of homocysteine and other aminothiol compounds are related to food intake in healthy human subjects
J Nutr, 124 (1994), pp. 1934-1941
27.
M. Den Heijer,G.M. Bos,I.A. Brouwer,W.B. Gerrits,H.J. Blom
Variability of the methionine loading test: no efect of a low protein diet
Ann Clin Biochem, 33 (1996), pp. 551-554
28.
R.Z. Stolzenberg-Solomon,E.R. Miller 3rd,M.G. Maguire,J. Selhub,L.J. Appel
Association of dietary protein intake and coffee consumption with serum homocysteine concentrations in an older population
Am J Clin Nutr, 69 (1999), pp. 467-475
29.
J. Mann,N. Dudman,X.W. Guo,P. Clarke,J. Mann,J.F. Simpson
The effect of diet on homocysteine levels in healthy male subjects
Neth J Med, 52 (1998), pp. S10
30.
W. Herrmann,H. Schorr,R. Obeid,J. Geisel
Vitamin B12 status, particularly holotranscobalamin II and methylmalonic acid concentracions, and hyperhomocysteinemia in vegetarians
Am J Clin Nutr, 78 (2003), pp. 131-136
31.
P. Verhoef,W.J. Pasman,T. Van Vliet,R. Urgert,M.B. Katan
Contribution of caffeine to the homocysteine-raising effect of coffe: a randomized controlled trial in humans
Am J Clin Nutr, 76 (2002), pp. 1244-1248
32.
C. Bergmark,M.A. Mansoor,J. Swedenborg,U. De Faire,A.M. Svardal,P.M. Ueland
Hyperhomocysteinemia in patients operated for lower extremity ischaemia below the age of 50-effect of smoking and extent of disease
Eur J Vasc Surg, 7 (1993), pp. 391-396
33.
A.M. Preston
Cigarette smoking-nutritional implications
Prog Food Nutr Sci, 15 (1991), pp. 183-217
34.
J.P. Eiserich,A. Van der Vliet,G.J. Handelman,B. Halliwell,C.E. Cross
Dietary antioxidants and cigarette smoke-induced biomolecular damage: a complex interaction
Am J Clin Nutr, 62 (1995), pp. S1490-S1500
35.
S.E. Vollset,O. Nygard,G. Kvale
The Hordaland Homocysteine Study lifestyle and total plasma homocysteine in Western Norway
Homocysteine metabolism: from basic science to clinical medicine, pp. 177-182
36.
D.A. De Luis,N. Fernandez,R. Aller,M. Arranz,O. Izaola
Relation between total homocysteine levels and beer consumption in diabetics type 2 patients
Annals of Nutrition, 47 (2003), pp. 119-123
37.
L.I. Mennen,G.P. De Courcy,J.C. Guilland,V. Ducros,M. Zarebska,S. Bertrais
Relation between homocysteine concentrations and the consumption of different types of alcoholic beberages: the French Supplementation with Antioxidant Vitamins and Minerals Study
Am J Clin Nutr, 78 (2003), pp. 334-338
38.
P.M. Ueland,H. Refsum,S.P. Stabler
Total homocysteine in plasma or serum. Methods and clinical applications
Clin Chem, 39 (1993), pp. 1764-1779
39.
H. Refsum,T. Fiskerstrand,A.B. Guttormsen,P.M. Ueland
Assessment of homocysteine status
J Inher Metab Dis, 20 (1997), pp. 286-294
40.
K. Rasmussen,J. Moller,M. Lyngbak
Withinperson variation of plasma homocysteine and effects of posture and tourniquet application
Clin Chem, 45 (1999), pp. 1850-1855
Correspondencia: Dr. D.A. de Luis. Instituto de Endocrinología y Nutrición. Los Perales, 16 (urbanización Las Aceñas). 47130 Simancas. Valladolid. España.
Copyright © 2004. Sociedad Española de Endocrinología y Nutrición