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Endocrinol Nutr 2006;53:218-21 - DOI: 10.1016/S1575-0922(06)71092-0
Nota clínica
Hipoglucemia por hiperinsulinemia endógena en el adulto
Hypoglycemia due to endogenous hyperinsulinism in an adult
V. Campos??, , J.C. Ferrer, I. Mascarell, A.L. Abad, J.F. Merino, F. Piñón
Servicio de Endocrinología y Nutrición. Hospital Universitari La Fe. Valencia. España
Recibido 26 agosto 2003, Aceptado 17 diciembre 2004

Nesidioblastosis is a well-known cause of hypoglycemia in neonates. However, it is poorly understood in adults, creating both diagnostic and therapeutic dilemmas.

Case report

A 63-year-old man presented with hyperinsulinemic hypoglycemia. An insulinoma was not identified prior to or during surgery, and subtotal pancreatectomy was performed. Histological examination revealed the presence of nesidioblastosis.


We identified a patient with severe hyperinsulinemic hypoglycemia due to diffuse islet cell disease. This etiology should always be considered in patients with a preoperative presumptive diagnosis of insulinoma. In these cases, partial pancreatectomy is indicated, although the optimal treatment remains to be determined.

Palabras clave
Nesidioblastosis, Adulto, Hipoglucemia, Hiperinsulinemia
Key words
Nesidioblastosis, Adult, Hypoglycemia, Hyperinsulinism
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Correspondencia: Dr. V. Campos-Alborg. Servicio de Endocrinología. Hospital Universitari La Fe. Avda. Campanar, 21. 46009 Valencia. España.
Copyright © 2006. Sociedad Espa??ola de Endocrinolog??a y Nutrici??n