¿Aún no está registrado?

Cree su cuenta. Regístrese en Elsevier y obtendrá: información relevante, máxima actualización y promociones exclusivas.

Registrarme ahora
Ayuda - - Regístrese - Teléfono 902 888 740
Buscar en

Indexada en:

Index Medicus/MEDLINE, Excerpta Medica/EMBASE, SCOPUS, Science Citation Index Expanded, Journal Citation Reports/Science Edition, IBECS


  • Factor de Impacto: 1,106(2016)
  • SCImago Journal Rank (SJR):0,314
  • Source Normalized Impact per Paper (SNIP):0,383

© Thomson Reuters, Journal Citation Reports, 2016

Endocrinol Nutr 2006;53:453-7 - DOI: 10.1016/S1575-0922(06)71131-7
Diagnóstico de localización del hiperparatiroidismo primario
Preoperative diagnostic localization of primary hyperparathyroidism
Elena Torres Vela, , Miguel Quesada Charneco
Servicio Endocrinología y Nutrición. Hospital Clínico San Cecilio. Granada. España
Recibido 30 enero 2006, Aceptado 13 marzo 2006

Primary hyperparathyroidism (PHPT) is a common endocrine disease. The presence of PHPT should be suspected in patients with persistent, often mild, hypercalcemia in the absence of any other apparent etiology. Hyperparathyroidism is the most frequent cause of hypercalcemia in the outpatient setting and is usually discovered incidentally by routine laboratory testing. Currently, most patients are asymptomatic. The only permanently effective therapy for patients with PHPT is surgery, with a high cure rate (95%) and few perioperative complications (5%). Parathyroid imaging is not required in the diagnosis of PHPT. The role of preoperative localization in patients undergoing initial neck exploration is unclear, since a bilateral approach in the hands of experienced surgeons achieves a high cure rate. Preoperative localization of adenomas with ultrasonography or sestamibi scanning allows a minimally invasive approach to be used. Localization studies are required when PHPT persists or recurs after surgery.

Palabras clave
Hiperparatiroidismo, Ecografía, Gammagrafía con sestamibi
Key words
Hyperparathyroidism, Ultrasonography, Sestamibi scan
El Texto completo solo está disponible en PDF
E. Lundgren,J. Rastad,E. Thrufjell,G. Akerstrom,S. Ljunghall
Population- based screening for primary hyperparathyroidism with serum calcium and parathyroid hormone values in menopausal women
Surgery, 121 (1997), pp. 287-294
The American Association of Clinical Endocrinologists and the American Association of Endocrine Surgeons Position Statement on the Diagnosis and Management of Primary Hyperparathyroidism. Endocr Pract. 2005; 11:49-54.
M. Muñoz-Torres,F. Escobar-Jiménez,J. Díaz Pérez De Madrid
Retos al diagnóstico hospitalario del hiperparatiroidismo primario
Med Clin (Barc), 93 (1989), pp. 209-210
J.P. Bilezikian,S.J. Silverberg
Clinical practice. Asymptomatic primary hyperparathyroidism
N Engl J Med, 350 (2004), pp. 1746-1751 http://dx.doi.org/10.1056/NEJMcp032200
S.J. Silverberg,E. Shane,T.P. Jacobs,E. Siris,J.P. Bilezikian
A 10- year prospective study of primary hyperparathyroidism with or without parathyroid surgery
N Engl J Med, 341 (1999), pp. 1249-1255 http://dx.doi.org/10.1056/NEJM199910213411701
M. Muñoz Torres,M. Ventosa Viñas,P. Mezquita Raya,V. Luna,F. López Rodríguez,D. Becerra
Utilidad de la densitometría ósea en la evaluación del hiperparatiroidismo primario
Med Clin (Barc), 114 (2000), pp. 521-524
S.J. Silverberg,J.P. Bilezikian,H.G. Bone,G.B. Talpos,M.J. Horwitz,A.F. Stewart
Therapeutic controversies in primary hyperparathyroidism
J Clin Endocrinol Metab, 84 (1999), pp. 2275-2285 http://dx.doi.org/10.1210/jcem.84.7.5842-1
J.T. Potts Jr
Proceedings of the NIH Consensus Development Conference on Diagnosis and Management of Asymptomatic Primary Hyperparathyroidism
J Bone Miner Res, 6 (1991), pp. S9-S13 http://dx.doi.org/10.1002/jbmr.5650061406
J.P. Bilezikian,J.T. Potts Jr,G-H. Fuleihan,M. Kleerekoper,R. Neer,M. Peacock
Summary statement from a workshop on asymptomatic primary hyperparathyroidism: a perspective for the 21st century
J Bone Miner Res, 17 (2002), pp. N2-N11
R.A. Kaplan,W.H. Snyder,A. Stewart,C.Y. Pak
Metabolic effects of parathyroidectomy in asymptomatic primary hyperparathyroidism
J Clin Endocrinol Metab, 42 (1976), pp. 415-426
A.K. Chan,Q.Y. Duh,M.H. Katz,A.E. Siperstein,O.H. Clark
Clinical manifestations of primary hyperparathyroidism before and after parathyroidectomy. A case-control study
Ann Surg, 222 (1995), pp. 402-412
T. Stefenelli,C. Abela,H. Frank,J. Koller-Strametz,S. Globits,J. Bergler-Klein
Cardiac abnormalities in patients with primary hyperparathyroidism: implications for follow-up
J Clin Endocrinol Metab, 82 (1997), pp. 106-112 http://dx.doi.org/10.1210/jcem.82.1.3666
S.J. Silverberg,F.G. Locker,J.P. Bilezikian
Vertebral osteopenia: a new indication for surgery in primary hyperparathyroidism
J Clin Endocrinol Metab, 81 (1996), pp. 4007-4012 http://dx.doi.org/10.1210/jcem.81.11.8923852
R. Nomura,T. Sugimoto,T. Tsukamoto,M. Yamauchi,H. Sowa,Q. Chen
Marked and sustained increase in bone mineral density after parathyroidectomy in patients with primary hyperparathyroidism; a six-year longitudinal study with or without parathyroidectomy in a Japanese population
Clin Endocrinol (Oxf), 60 (2004), pp. 335-342
J.A. Sosa,N.R. Powe,M.A. Levine,R. Udelsman,M.A. Zeiger
Profile of a clinical practice: thresholds for surgery and surgical outcomes for patients with primary hyperparathyroidism: a national survey of endocrine surgeons
J Clin Endocrinol Metab, 83 (1998), pp. 2658-2665
S.R. Schell,N.E. Dudley
Clinical outcomes and fiscal consequences of bilateral neck exploration for primary idiopathic hyperparathyroidism without preoperative radionuclide imaging or minimally invasive techniques
Surgery, 133 (2003), pp. 32-39 http://dx.doi.org/10.1067/msy.2003.88
I.L. Nilsson,L. Yin,E. Lundgren,J. Rastad,A. Ekbom
Clinical presentation of primary hyperparathyroidism in Europe –nationwide cohort analysis on mortality from nonmalignant causes
J Bone Miner Res, 17 (2002), pp. N68-N74
M. Yao,C. Jamieson,R. Blend
Magnetic resonance imaging in preoperative localization of diseased parathyroid glands: a comparison with isotope scanning and ultrasonography
Can J Surg, 36 (1993), pp. 241-244
M.S. Weinberger,K.T. Robbins
Diagnostic localization studies for primary hyperparathyroidism. A suggested algorithm
Arch Otolaryngol Head Neck Surg, 120 (1994), pp. 1187-1189
B.K. Mitchell,B.K. Kinder,E. Cornelius,A.F. Steward
How should patients with primary Hyperparathyroidism be treated?
J Clin Endocrinol Metab, 88 (2003), pp. 3011-3014 http://dx.doi.org/10.1210/jc.2003-030588
M. Ishibashi,H. Nishida,Y. Hiromatsu,K. Kojima,E. Tabuchi,N. Hayabuchi
Comparison of technetium-99m-MIBI, technetium- 99m-tetrofosmin, ultrasound and MRI for localization of abnormal parathyroid glands
J Nucl Med, 39 (1998), pp. 320-324
H. Takami,S. Satake,K. Nakamura,A. Kubo
What are the indications for 99mTc-sestamibi scintigraphy in hyperparathyroidism?
Clin Endocrinol (Oxf), 45 (1996), pp. 121
P. Thule,K. Thakore,J. Vansant,W. McGarity,C. Weber,L.S. Phillips
Preoperative localization of parathyroid tissue with technetium-99m sestamibi 123I subtraction scanning
J Clin Endocrinol Metab, 78 (1994), pp. 77-82 http://dx.doi.org/10.1210/jcem.78.1.8288719
D.J. Halvorson,G.J. Burke,A.R. Mansberger Jr,J.P. Wei
Use of technetium Tc99m sestamibi and iodine 123 radionuclide scan for preoperative localization of abnormal parathyroid glands in primary hyperparathyroidism
South Med J, 87 (1994), pp. 336-339
E. Hindie,D. Melliere,L. Perlemuter,C. Jeanguillaume,P. Galle
Primary hyperparathyroidism: higher success rate of first surgery after preoperative Tc-99sestamibi-I-123 subtraction scanning
A.C. Civelek,E. Ozalp,P. Donovan,R. Udelsman
Prospective evaluation of delayed technetium-99m sestamibi SPECT scintigraphy for preoperative localization of primary hyperparathyroidism
Surgery, 131 (2002), pp. 149-157
S.M. Roe,P.W. Brown,L.M. Pate,J.B. Summitt,D.L. Ciraulo,R.P. Burns
Initial cervical exploration for parathyroidectomy is not benefited by preoperative localization studies
Am Surg, 64 (1998), pp. 503-507
E.D. Dillavou,J.S. Jenoff,C.M. Intenzo,H.E. Cohn
The utility of sestamibi scanning in the operative management of patients with primary hyperparathyroidism
J Am Coll Surg, 190 (2000), pp. 540-545
J. Allendorf,L. Kim,J. Chabot,M. DiGiorgi,K. Spanknebel,P. Lo- Gerfo
The impact of sestamibi scanning on the outcome of parathyroid surgery
J Clin Endocrinol Metab, 88 (2003), pp. 3015-3018 http://dx.doi.org/10.1210/jc.2002-021095
N. Jaskowiak,J.A. Norton,H.R. Alexander,J.L. Doppman,T. Shawker,M. Skarulis
A prospective trial evaluating a standard approach to reoperation for missed parathyroid adenoma
Ann Surg, 224 (1996), pp. 308-320
W. Shen,M. Duren,E. Morita,C. Higgins,Q.Y. Duh,A.E. Siperstein
Reoperation for persistent or recurrent primary hyperparathyroidism
Arch Surg, 131 (1996), pp. 861-867
H.R. Alexander Jr,C.C. Chen,T. Shawker,P. Choyke,T.J. Chan,R. Chang
Role of preoperative localization and intraoperative localization maneuvers including intraoperative PTH assay determination for patients with persistent or recurrent hyperparathyroidism
J Bone Miner Res, 17 (2002), pp. N133-N140
K.E. Levin,G.A. Gooding,M. Okerlund,C.B. Higgins,D. Norman,T.H. Newton
Localizing studies in patients with persistent or recurrent hyperparathyroidism
Surgery, 102 (1987), pp. 917-925
J.A. Pallotta,B.A. Sacks,D.E. Moller,H. Eisenberg
Arteriographic ablation of cervical parathyroid adenomas
J Clin Endocrinol Metab, 69 (1989), pp. 1249-1255 http://dx.doi.org/10.1210/jcem-69-6-1249
M.P. MacFarlane,D.L. Fraker,H. Shawker,J.A. Norton,J.L. Doppman,R.A. Chang
Use of preoperative fine-needle aspiration in patients undergoing reoperation for primary hyperparathyroidism
Surgery, 116 (1994), pp. 959-964
D.L. Miller,J.L. Doppman,A.G. Krudy,T.H. Shawker,J.A. Norton,J.J. Vucich
Localization of parathyroid adenomas in patients who have undergone surgery. Part II. Invasive procedures
J. Norman,H. Chheda,C. Farrell
Minimally invasive parathyroidectomy for primary hyperparathyroidism: decreasing operative time and potential complications while improving cosmetic results
Am Surg, 64 (1998), pp. 391-395
N.D. Perrier,P. Ituarte,E. Morita,T. Hamil,R. Gielow,Q.Y. Duh
Parathyroid surgery: Separating promise for reality
J Clin Endocrinol Metab, 87 (2002), pp. 1024-1029 http://dx.doi.org/10.1210/jcem.87.3.8310
G.L. Irvin III,A.S. Molinari,A.C. Figueroa,D.M. Carneiro
Improve success rate in reoperative parathyroidectomy with intraoperative PTH assay
Am Surg, 229 (1999), pp. 874-878
P.C. Gauger,G. Agarwal,B.G. England,L.W. Delbridge,K.A. Matz,M. Wilkinson
Intraoperative parathyroid hormone monitoring fails to detect double parathyroid adenomas: a 2 institution experience
Surgery, 130 (2001), pp. 1005-1010
Correspondencia: Dra. E. Torres Vela Luis Braille, 7, 1.° A. 18005 Granada. España. (Elena Torres Vela etorresvela@gmail.com)
Copyright © 2006. Sociedad Española de Endocrinología y Nutrición