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Indexada en:

Index Medicus/MEDLINE, Excerpta Medica/EMBASE, SCOPUS, Science Citation Index Expanded, Journal Citation Reports/Science Edition, IBECS

Métricas

  • Factor de Impacto: 1,314(2015)
  • SCImago Journal Rank (SJR):0,28
  • Source Normalized Impact per Paper (SNIP):0,383
doi: 10.1016/S1575-0922(06)71130-5
Notas clínicas
Beneficios de la metformina en el embarazo de las mujeres con síndrome del ovario poliquístico: a propósito de un caso
Benefits of metformin in pregnant women with polycystic ovary syndrome: a case report
Teresa Pedro Font, Francisco Javier Ampudia-Blasco, , Rafael Carmena
Unidad de Referencia de Diabetes. Servicio de Endocrinología y Nutrición. Hospital Clínico Universitario. Valencia. España
Recibido 25 noviembre 2005, Aceptado 23 enero 2006
Resumen

El síndrome del ovario poliquístico (SOP) es una enfermedad frecuente (5-10% de mujeres en edad reproductiva) que se asocia con diabetes tipo 2, obesidad y alteraciones en el eje reproductivo, debido a la resistencia a la insulina y el hiperinsulinismo, entre otros factores. En mujeres con SOP, el tratamiento con metformina durante el embarazo se ha asociado a una disminución del riesgo de aborto precoz al mejorar la función endometrial y la implantación del embrión. Además, este fármaco reduce la frecuencia de diabetes gestacional, generalmente elevada en las mujeres embarazadas con SOP. El caso clínico describe la consecución de un embarazo a término en una mujer con SOP y diabetes tipo 2 tratada con metformina durante el período de fertilización y primera mitad de la gestación, tras 3 intentos fallidos en los que se suprimió el fármaco antes de la fertilización in vitro.

Resumen

Polycystic ovary syndrome (PCOS) is a frequent disease that affects 5-10% of women of reproductive age. This entity has been associated with metabolic disturbances, such as type 2 diabetes and obesity, and alterations of the reproductive axis due to insulin resistance and hyperinsulinism, among other factors. In pregnant women with PCOS, metformin therapy has been associated with a reduction in spontaneous abortion due to improved endometrial function and embryo implantation. Furthermore, the drug reduces the frequency of gestational diabetes mellitus, which is generally increased in pregnant women with PCOS. We describe a case of term pregnancy in a woman with PCOS and type 2 diabetes, who was treated with metformin during the fertilization period and the first half of pregnancy, following three failed attempts in which the drug was discontinued before in vitro fertilization.

Palabras clave
Síndrome del ovario poliquístico, Metformina, Diabetes tipo 2, Gestación, Aborto
Key words
Polycystic ovary syndrome, Metformin, Type 2 diabetes, Pregnancy, Abortion
El Texto completo solo esta disponible en PDF
Bibliografía
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Correspondencia: Dr. F.J. Ampudia-Blasco. Unidad de Referencia de Diabetes. Servicio de Endocrinología y Nutrición. Hospital Clínico Universitario. Avda. Blasco Ibáñez, 17. 46010 Valencia. España.
Copyright © 2006. Sociedad Española de Endocrinología y Nutrición