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  • Factor de Impacto: 1,106(2016)
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Endocrinol Nutr 2007;54:325-7 - DOI: 10.1016/S1575-0922(07)71457-2
Notas clínicas
Acidosis láctica por metformina
Metformin-induced lactic acidosis
Laura de la Maza Pereg??, , Víctor Manuel García Hierro, Pilar Álvarez Baños, Javier Pi Barrio, Luis Castillo López, Enrique Ruiz Pérez
Sección de Endocrinología y Nutrición. Hospital General Yagüe. Burgos. España
Recibido 14 marzo 2005, Aceptado 13 noviembre 2006
Resumen

Lactic acidosis is an uncommon side effect of metformin use, which is more likely to arise in patients with certain predisposing factors.

We present the case of a patient with hypertension treated with indapamide and captopril and type 2 diabetes mellitus treated with insulin and metformin.

Previous renal function was normal. After taking non-steroidal anti-inflammatory drugs, the patient developed vomiting, abdominal pain, diarrhea, oliguria, and lactic acidosis.

Tests on admission showed urea 227mg/dl, creatinine 13.2mg/dl, pH 6.98, bicarbonate 7.1mmol/l, and lactic acid 105.4mg/dl (normal below 19.8mg/dl). After two hemodialysis sessions, the patient improved, although kidney failure persisted after discharge.

Lactic acidosis is a serious complication of metformin therapy and is more frequent in patients with kidney failure and other intercurrent complaints.

Palabras clave
Metformina, Acidosis láctica, Insuficiencia renal
Key words
Metformin, Lactic acidosis, Kidney failure
El Texto completo solo está disponible en PDF
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Correspondencia: Dra. L. de la Maza Pereg. Sección de Endocrinología y Nutrición. Hospital General Yagüe. Avda. del Cid, 96. 09005 Burgos. España. (Laura de la Maza Pereg alonsomaza@ono.com)
Copyright © 2007. Sociedad Española de Endocrinología y Nutrición