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Vol. 73. Núm. 4.
Páginas 244-251 (Abril 2003)
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Vol. 73. Núm. 4.
Páginas 244-251 (Abril 2003)
Acceso a texto completo
Bipartición hepática
Hepatic bipartition
Visitas
9727
Emilio Vicentea,1
Autor para correspondencia
emilvic@bitmailer.net

Correspondencia: Dr. E. Vicente. Unidad de Trasplante Hepato-Intestinal. Hospital Ramón y Cajal. Ctra. Colmenar, Km 9,100. 28034 Madrid. España.
, Manuel López-Santamaríab, Javier Nuñoa, Manuel Gámezb, Javier Murciab, Yolanda Quijanoa, Pedro López-Hervása, José A. Tovarb, Paloma Jarab, Esteban Fraucb, Alberto Honrubiaa, Gemma Mongea, Rafael Bárcenaa, Miguel Garcíaa, Adolfo Martíneza, Arancha Puentea, Ana Domíngueza, Gustavo Zarzosaa
a Departamento de Cirugía General y Digestiva. Unidad de Trasplante Hepato-Intestinal. Hospital Ramón y Cajal. Universidad de Alcalá de Henares
b Departamento de Cirugía Pediátrica. Unidad de Trasplante Hepato-Intestinal. Hospital Infantil La Paz. Universidad Autónoma de Madrid. Madrid. España
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Resumen

La bipartición hepática representa en la actualidad un procedimiento de elección para el trasplante hepático de donante cadáver. La escasez del número de donantes existentes y el constante incremento en el número de receptores avalan este hecho. La realización de este procedimiento obliga a un riguroso protocolo de selección del donante, a una cuidadosa logística en la donación con el objetivo de no prolongar los tiempos de isquemia y al establecimiento de un consenso entre los dos equipos que van a realizar los dos implantes, a efectos de atender sus necesidades en función de la situación del receptor y las características anatómicas, y poder realizar una lógica repartición de los pedículos vasculobiliares. Dos procedimientos técnicos han sido descritos: procedimiento ex vivo e in situ. Este último está asociado con una menor incidencia de complicaciones quirúrgicas, hemorragia postoperatoria, trombosis de las reconstrucciones vasculares realizadas, complicaciones biliares y necrosis de áreas hepáticas. Si bien la bipartición hepática para un receptor adulto y otro pediátrico está claramente justificada, más dificultades existen para su realización con dos receptores adultos. Sólo debe plantearse ser efectuado con dos adultos de bajo peso, en donde el volumen hepático a implantar sea el adecuado. Los resultados obtenidos con la bipartición hepática confirman el gran beneficio para los programas pediátricos en función de la reducción de su lista de espera y las mínimas consecuencias en términos de complicaciones postoperatorias o pérdidas de injertos para los programas de adultos.

Palabras clave:
Trasplante hepático
Trasplante hepático reducido
BIpartición hepática
Trasplante hepático partido

Hepatic bipartition currently represents a treatment of choice for liver transplantation from cadaveric donors. This is supported by the scarcity of donors and the constant increase in the number of recipients. This procedure requires a rigorous protocol for donor selection and careful logistics during donation to prevent prolonged times of ischemia. Consensus between the two teams performing the transplantations is also required to meet their needs according to the recipients’ status and anatomical characteristics and to be able to perform a logical division of the vascular- biliary pedicles. Two technical procedures have been described: ex vivo and in situ procedures. The latter is associated with a lower incidence of surgical complications, postoperative hemorrhage, thrombosis of the vascular reconstructions performed, biliary complications, and necrosis of the hepatic areas. Although hepatic bipartition for one adult and one pediatric recipient is clearly justified, the difficulties are greater when both receptors are adults. Only when both adults are of low body weight and the hepatic volume to be implanted is sufficient should the procedure be performed. The results obtained with hepatic bipartition confirm its great benefits in pediatric programs in terms of reduced waiting lists and its scarce repercussions in terms of postoperative complications and graft loss in adult programs.

Key words:
Liver transplantation
Reduced liver transplantation
Liver bipartition
Split liver transplantation
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Bibliografía
[1.]
Memoria Anual de la Organización Nacional de Trasplantes, 2001.
[2.]
D. Azoulay, D. Samuel, D. Castaing, R. Adam, D. Adams, et al.
Domino liver transplants for metabolic disorders: experience with familial amyloidotic polyneuropathy.
J Am Coll Surg, 189 (1999), pp. 584-593
[3.]
C.E. Broelsch, J.C. Emond, P.F. Whitington, J.R. Thistlethwaite, A.L. Baker, J.L. Lichtor.
Application of reduced-size liver transplants as split grafts, auxiliary orthotopic grafts and living related segmental transplants.
Ann Surg, 212 (1990), pp. 368-377
[4.]
European Liver Transplant Registry. Data Analysis Booklet. 05/1968—12/2000|.
[5.]
R. Pichlmayr, B. Ringe, G. Gubernatis, J. Hauss, H. Bonzondahl.
Transplantation einer Spenderleber auf zwei Empfänger (Splitting- Transplantation.
Eine neue Methode in der Weiterentwicklung der Lebersegmenttransplantation Langenbecks Arch Chir, 373 (1988), pp. 127-130
[6.]
H. Bismuth, M. Morino, D. Castaing, M.C. Gillon, A. Descorps Dedere, F. Saliba, D. Samuel.
Emergency orthotopic liver transplantation in two patients using one donor liver.
Br J Surg, 76 (1989), pp. 722-724
[7.]
X. Rogiers, M. Malagó, K.A. Gawad, R. Huhlencordt, G. Fröschle, E. Sturm, et al.
One year ox experience with extended application and modified techniques of split liver transplantation.
Transplantation, 61 (1996), pp. 1059-1061
[8.]
X. Rogiers, M. Malagó, K.A. Gawad, K.W. Jauch, M. Olausson, W.T. Knoefel, et al.
In situ splitting of cadaveric livers. The ultimate expansion of a limited donor pool.
Ann Surg, 224 (1996), pp. 331-341
[9.]
J.C. Emond, P.F. Whitington, J.R. Thistlethwaite, M.A. Estella, C.E. Broelsch.
Reduced-size orthotopic liver transplantation: use in the management of children with chronic liver disease.
Hepatology, 10 (1989), pp. 867-872
[10.]
J.B. Otte, J. De Ville de Goyet, D. Alberti, P. Balladur, B. Hemptinne.
The concept and technique of the split liver in clinical transplantation.
Surgery, 107 (1990), pp. 605-612
[11.]
J.C. Emond, P.F. Whitington, J.R. Thistlethwaite, D. Cherqui, E.A. Alonso, I.S. Woodle, et al.
Transplantation of two patients with one liver.
Ann Surg, 212 (1990), pp. 14-22
[12.]
D. Houssin, C. Couinaud, O. Boillot, J. Laurent, N. Habib, M. Matmar, et al.
Controlled hepatic bipartition for transplantation in children.
Br J Surg, 78 (1991), pp. 802-804
[13.]
A.L. Langnas, W.C. Marujo, M. Inagaki, R.J. Stratta, R.P. Wood, B.W. Shaw.
The results of reduced-size liver transplantation, including split livers, in patients with end-stage liver disease.
Transplantation, 53 (1992), pp. 387-391
[14.]
D. Houssin, O. Boillot, O. Soubrane, C. Couinaud, J. Pitre, Y. Ozier, et al.
Controlled liver splitting for transplantation in two recipients: technique, results and perspectives.
Br J Surg, 80 (1993), pp. 75-80
[15.]
J. De Ville de Goyet.
Split Liver transplantation in Europe- 1988 to 1993.
Transplantation, 59 (1995), pp. 1371-1376
[16.]
M. Kalayoghu, A.M. D’Alesasandro, S.J. Knechtle, R.M. Hoffmann, J.D. Pirsch, R.H. Judd, et al.
Preliminary experience with split liver transplantation.
J Am Coll Surg, 182 (1996), pp. 381-387
[17.]
T. Karbe, X. Rogiers, M. Malago, R. Kütermeier, R. Kuhlencordt, C.E. Broelsch.
Technical procedures and logistics of split-liver tranplantation.
Transplant Proc, 28 (1996), pp. 3345-3346
[18.]
K.A. Gawad, X. Rogiers, M. Malagó, M. Gunlach, W.T. Knoefel, J.R. Izbicki, et al.
Optimisation of donor organ usage with the extended application of split-liver, reduced size and living liver transplantation: a 1-year experience.
Transplant Proc, 28 (1996), pp. 54-55
[19.]
D.A. Azoulay, I. Astarcioglu, H. Bismuth, D. Castaing, P. Majno, R. Adam, et al.
Split-liver transplantation. The Paul Brousse policy.
Ann Surg, 224 (1996), pp. 737-748
[20.]
M. Rela, V. Vougas, P. Muiessan, V. Smymiotis, P. Gibbs, R. Williams, et al.
Split liver transplantation: a way forward?.
Transplant Proc, 29 (1997), pp. 562-563
[21.]
R.W. Bussuttil, J.A. Goss.
Split liver transplantation.
Ann Surg, 229 (1999), pp. 313-321
[22.]
S. Kawasaki, M. Makuuchi, H. Matsunami, Y. Hashikura, T. Ikegami, H. Chisuwa, et al.
Preoperative measurement of segmental liver volume of donors for living related liver transplantation.
Hepatology, 18 (1993), pp. 115-120
[23.]
K. Urata, S. Kawasaki, H. Matsunami, Y. Hashikura, T. Ikegami, S. Ishizone, et al.
Calculation of child and adult standard liver volume for liver transplantation.
Hepatology, 21 (1995), pp. 1317-1321
[24.]
E. Chaib, M.M. Morales, M.B. Bordalo, L.G. Antonio, L.F. Feijo, R.Y. Ishida, et al.
Predicting the donor liver lobe weight from body weight for split-liver transplantation.
Braz J Med Biol Res, 28 (1995), pp. 759-760
[25.]
T.E. Starzl, C. Miller, B. Broznick, L. Makowka.
An improved technique for multiple organ harvesting.
Surg Gynecol Obstet, 165 (1987), pp. 343-348
[26.]
M. Gundlach, D. Broering, S. Topp, M. Sterneck, X. Rogiers.
Split-cava technique: liver splitting for two adult recipients.
Liver Transpl, 6 (2000), pp. 703-706
[27.]
D.G.l. Farmer.
Postransplant complications of the split liver transplant recipients.
The first International Symposium Dedicated to expanding the donor pool. Living donor and split liver transplantation symposium. Pittsburgh, (August, 1999),
[28.]
M. Malago.
Intraoperative complications in split liver transplantation. The second International Symposium Dedicated to expanding the donor pool.
[29.]
J. Reyes.
Split liver transplantation: a comparison of ex vivo and in situ techniques. The second International Symposium Dedicated to expanding the donor pool.
[30.]
B. Gridelli.
The second International Symposium Dedicated to expanding the donor pool.
[31.]
Heaton N. The second International Symposium Dedicated to expanding the donor pool. Living donor and split liver transplantation symposium. Roma, August 2000.
[32.]
M. Colledan, E. Adorno, U. Valente, B. Gridelli.
A new spliting techniques for liver grafts.
[33.]
D. Sommacale, O. Farges, G.M. Ettore, P. Lebigot, A. Souvanet, J. Marty, et al.
In situ split liver transplantation for two adults recipients.
Transplantation, 69 (2000), pp. 1005-1007
[34.]
E. Adorno, E. Genzone, N. Morelli, R. Mondello, M. Colledan, B. Gridelli, et al.
One liver for two adults: in situ split liver transplantation for two adults.
Transplant Proc, 33 (2001), pp. 1420-1422
[35.]
D. Azoulay, D. Castaing, R. Adam, E. Savier, V. Delvart, V. Karam, et al.
Split-liver transplantation for two adult recipients: feasibility and long-term outcomes.
Ann Surg, 233 (2001), pp. 565-574
[36.]
Broering DC, Gundlach M, Topp S, Mueller L, Rogiers X. In situ full

Estudio financiado por la Foundation for Liver Transplantation Development.

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