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Acta Otorrinolaringol Esp 2003;54:31-8 - DOI: 10.1016/S0001-6519(03)78381-2
Linfomas de fosas nasales, consideraciones clínicas y anatomo-patológicas
Lymphoma of the nasal cavity, clinical and anatomopathological considerations
F. Márquez1, P. Escobar, J.M. Villacampa, J. Sanabria, R. Gutiérrez, C. Cenjor
Servicio de Otorrinolaringología
C. Méndez, C. Rivas
* Servicio de Anatomía Patológica. Fundación Jiménez Díaz. Universidad Autónoma. Madrid
Recibido 04 julio 2002, Aceptado 04 noviembre 2002

Six cases of high-grade lymphoma affecting the nasal cavity are presented. Their main symptoms were nasal obstruction, epistaxis and rhinorrea. Clinical exploration showed an ulcerated lesion in four patients (all of them T/NK cell lymphomas) and an exofitic tumour in the other two (B cell lymphomas). Pathology was diagnostic for high grade lymphoma in all the six cases, immunohistochemical studies revealed that the atypical cells were T/NK in 4 cases and B in the other two cases. Genotypic analysis was done looking for rearrangement of the genes for Ig H or T-cell receptors. In situ hybridisation was done to detect Epstein-Barr virus RNA. Malignant lymphomas arising in the nasal cavity are unusual, its major prognostic factor is the clinical stage at presentation. To perform an early diagnosis this neoplasia must be suspected in the presence of an exofitic tumour (B cell lymphoma) or necrotic and ulcerated lesion (T/NK cell lymphoma).

Palabras clave
Linfomas no Hodgkin, Linfomas nasales, Tumores nasales
Key words
Non-Hodgkin´s lymphoma, Nasal lymphoma, Nasal tumour
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Correspondencia: Servicio de Otorrinolaringología. Fundación Jiménez Díaz. Avda. Reyes Católicos, 2. 28040 Madrid. (F. Márquez )
Copyright © 2003. Elsevier España, S.L.