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Acta Otorrinolaringol Esp 2003;54:31-8 - DOI: 10.1016/S0001-6519(03)78381-2
Linfomas de fosas nasales, consideraciones clínicas y anatomo-patológicas
Lymphoma of the nasal cavity, clinical and anatomopathological considerations
F. Márquez1, P. Escobar, J.M. Villacampa, J. Sanabria, R. Gutiérrez, C. Cenjor
Servicio de Otorrinolaringología
C. Méndez, C. Rivas
* Servicio de Anatomía Patológica. Fundación Jiménez Díaz. Universidad Autónoma. Madrid
Recibido 04 julio 2002, Aceptado 04 noviembre 2002
Resumen
Resumen

Se presentan 6 casos de linfomas de alto grado que afectaban la cavidad nasal. Clínicamente los síntomas principales fueron obstrucción nasal, epístaxis y rinorrea. La exploración puso de manifiesto una lesión ulcerada en 4 casos (todos ellos linfomas T/NK) y exofítica en los otros dos (linfomas B). La histología fue diagnóstica para linfoma de alto grado en los 6 casos, la inmunohistoquímica reveló que las células atípicas eran T/NK en 4 casos, y B en los dos restantes. Se realizó un estudio de biología molecular buscando reordenamiento para Ig H y receptores de células T, e hibridación in situ para establecer relación con el virus de Epstein-Barr. Los linfomas nasales son tumores de aparición poco frecuente, su extensión es el factor que en mayor medida condiciona el pronóstico. Para diagnosticarlos precozmente su presencia debe sospecharse tanto en lesiones exofíticas (linfomas B) como en necróticas ulceradas (linfomas T/NK).

Resumen
Abstract

Six cases of high-grade lymphoma affecting the nasal cavity are presented. Their main symptoms were nasal obstruction, epistaxis and rhinorrea. Clinical exploration showed an ulcerated lesion in four patients (all of them T/NK cell lymphomas) and an exofitic tumour in the other two (B cell lymphomas). Pathology was diagnostic for high grade lymphoma in all the six cases, immunohistochemical studies revealed that the atypical cells were T/NK in 4 cases and B in the other two cases. Genotypic analysis was done looking for rearrangement of the genes for Ig H or T-cell receptors. In situ hybridisation was done to detect Epstein-Barr virus RNA. Malignant lymphomas arising in the nasal cavity are unusual, its major prognostic factor is the clinical stage at presentation. To perform an early diagnosis this neoplasia must be suspected in the presence of an exofitic tumour (B cell lymphoma) or necrotic and ulcerated lesion (T/NK cell lymphoma).

Palabras clave
Linfomas no Hodgkin, Linfomas nasales, Tumores nasales
Key words
Non-Hodgkin´s lymphoma, Nasal lymphoma, Nasal tumour
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Referencias
1.
I. Cuadra-García,G.M. Proulx,C. Lee Wu,C.C. Wang,B.Z. Pilch,N.L. Harris,J.A. Ferry
Sinonasal Lymphoma
Am J Surg Pathol, 23 (1999), pp. 1356-1369
2.
C. Rivas,A.G. Ageitos
Procesos linfoproliferativos de cabeza y cuello. Morfopatología y consideraciones clínico terapéuticas
pp. 3530-3545
3.
P.G. Isaacson,A.J. Norton
Malignant lymphomas of the upper aerodigestive tract
pp. 193-517
4.
J.A. Ferry,J. Sklar,L.R. Zukerberg,N.L. Harris
Nasal lymphoma. A Clincopathologic study with immunophenotypic and genotypic analysis
Am J Surg Pathol, 15 (1991), pp. 268-279
5.
M.A. Climent,C. Pallares Curto,R. Blanco Guerrero,J.M. Segui Palmer,J.R. Germa Lluch,L. de Andres Basauri
Linfomas originados en el área otorrinolaringológica: experiencia de 10 años
Med Clin, 97 (1991), pp. 565-568
6.
M.D. Logsdon,C.S. Ha,V.S. Kavadi,F. Cabanillas,M.A. Hess,J.D. Cox
Lymphoma of the nasal cavity and paranasal sinuses: improved outcome and altered prognostic factors with combined modality therapy
Cancer, 80 (1997), pp. 477-488
7.
G. Fajardo-dolci,R.C. Magana,E.L. Bautista,D. Huerta
Sinonasal lymphoma
Otolaryngol Head Neck Surg, 121 (1999), pp. 323-326
8.
E.S. Jaffe,J.K. Chan,I.J. Su,G. Frizzera,S. Mori,A.C. Feller
Report of the Workshop on Nasal and Related Extranodal Angiocentric T/Natural Killer Cell Ly m p h o m a s. Definitions, differential diagnosis, and epidemiology
Am J Surg Pathol, 20 (1996), pp. 103-111
9.
C.S. Chim,G.C. Ooi,T.W. Shek,R. Liang,Y.L. Kwong
Lethal midline granuloma revisited: nasal T/Natural- killer cell lymphoma
J Clin Oncol, 17 (1999), pp. 1322-1325
10.
J.K. Chan,V.C. Sin,K.F. Wong,C.S. Ng,W.Y. Tsang,C.H. Chan
Nonnasal lymphoma expressing the natural killer cell marker CD56: a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm
Blood, 89 (1997), pp. 4501-4513
11.
L. Quintanilla-Martinez,J.L. Franklin,I. Guerrero,L. Krenacs,K.N. Naresh,C. Rama-Rao,K. Bhatia
Histological and immunophenotypic profile of nasal NK/T cell lymphomas from Peru: high prevalence of p53 overexpression
Hum Pathol, 30 (1999), pp. 849-855
12.
T. Li,T. Hongyo,M. Syaifudin,T. Nomura,Z. Dong,N. Shingu
Mutations of the p53 gene in nasal N K / T-cell lymphoma
Lab Invest, 80 (2000), pp. 493-499
13.
A.K. Chiang,A.C. Chan,G. Srivastava,F.C. Ho
Nasal T/natural killer (NK)-cell lymphomas are derived from Epstein-Barr virus-infected cytotoxic lymphocytes of both NK- and T-cell lineage
Int J Cancer, 73 (1997), pp. 332-338
14.
A.L. Cavalot,E. Ricci,G. Nazionale,F. Palonta,G.L. Fadda
Primary non-Hodgkin's lymphoma of the nasal cavity. Clinical case report and discussion
Acta Otolaryngol, 120 (2000), pp. 545-550
15.
Y.X. Li,P.A. Coucke,J.Y. Li,D.Z. Gu,X.F. Liu,L.Q. Zhou
Primary non-Hodgkin's lymphoma of the nasal cavity: prognostic significance of paranasal extension and the role of radiotherapy and chem o t h e r a p y
Cancer, 83 (1998), pp. 449-456
16.
M.S. Quraishi,E.M. Bessell,D. Clark,N.S. Jones,P.J. Bradley
Non- Hodgkin's lymphoma of the sinonasal tract
Laryngoscope, 110 (2000), pp. 1489-1492
17.
A. Aviles,N.R. Diaz,N. Neri,S. Cleto,A. Talavera
Angiocentric nasal T/natural killer cell lymphoma: a single centre study of prognostic factors in 108 patients
Clin Lab Haematol, 22 (2000), pp. 215-220
18.
M.M. Cheung,J.K. Chan,W.H. Lau,W. Foo,P.T. Chan,C.S. Ng
Primary non-Hodgkin's lymphoma of the nose and nasopharynx: clinical features, tumor immunophenotype, and treatment outcome in 11 3 patients
J Clin Oncol, 16 (1998), pp. 70-77
19.
M.J. García,B. Martínez-Delgado,J.J. Granizo,J. Benitez,C. Rivas
Igh, tcr-gamma, and tcr beta gene rearrangement in 80 b- and t-cell nonhodgkin ´s lymphomas: study of the association between proliferation ando the so-called "aberrant" patterns
Diagn Mol Pathol, 10 (2001), pp. 69-77
Correspondencia: Servicio de Otorrinolaringología. Fundación Jiménez Díaz. Avda. Reyes Católicos, 2. 28040 Madrid.
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