The analysis of Hymenoptera hypersensitive patients in Ankara, Turkey

Published in Allergol Immunopathol (Madr). 2012;40:9-13. - vol.40 núm 01

Abstract

Background

Although there are some published data about the prevalence of honeybee and vespid venom allergy from Turkey, there has been no report about Hymenoptera venom immunotherapy practice. Our aim was to determine the characteristics of Hymenoptera venom hypersensitivity and venom immunotherapy practice in Ankara, Turkey.

Methods

Demographic and clinical data, intradermal test, and serum specific IgE results of 65 Hymenoptera venom allergic patients who were followed up in our department from February 2005 to August 2009 were analysed.

Results

Serum Vespula specific IgE class (p:0.02) and Apis specific IgE class were high (p<0.0001) and Apis intradermal test results were positive (p<0.001) in accordance with the patients’ history. However, intradermal test results with Vespula were not consistent with self-reported Hymenoptera type (p:0.15). While Apis specific IgE and intradermal test results were correlated with each other (rho: 0.59, p<0.0001), Vespula specific IgE and intradermal test results were not (rho: 0.2, p:0.17). Intradermal test against Vespula did not discriminate between Apis and Vespula hypersensitive patients. There were no significant differences when the grade of reaction and specific IgE and intradermal test results were compared between Apis and Vespula.

Conclusions

Vespula venom hypersensitivity was more common among our patients. However, intradermal tests with Vespula had limited diagnostic sensitivity and were not correlated with serum specific IgE. Based on our results and previous reports, we recommend that negative skin test responses, especially with Vespula, need further investigation.

Key words: Hymenoptera. Apis Mellifera. Vespula Vulgaris. Venom immunotherapy. Intradermal test. Venom hypersensitivity. Bee allergy.

Introduction

Introduction Hymenoptera venom can lead to systemic allergic reactions in up to 5% of the population in Europe and North America.1 In Turkey, the lifetime incidence of sting exposure and the incidence of systemic and severe systemic reaction rates were estimated to be 94.5%, 7.5%, and 2.2%, respectively.2 In children aged 6- 13 years, the lifetime cumulative sting prevalence and severe systemic reaction incidence were estimated to be 60.8% and 0.2%, respectively.3 It has been noted that Hymenoptera stings were most often caused by the honeybee, Apis Mellifera, and the vespid, Vespula Vulgaris, in Turkey.4 To identify species of the offending insect, recommend treatment, and educate patients about avoidance measures, patients should undergo a diagnostic evaluation.5 A detailed and careful history can usually establish the diagnosis of Hymenoptera sting reaction.5 However, sensitisation should be confirmed by a skin test reaction to venom or the detection of venom-specific IgE-antibodies to identify the responsible species, because there may be recall bias.6 The sensitivity and specificity of the utilised diagnostic tests are important for the correct diagnosis. Although there are some published data about the prevalence of honeybee (apis) and vespid (vespula) venom allergy, there has been no report about Hymenoptera venom immunotherapy practice from our country. Our aim was to determine the characteristics of Hymenoptera venom hypersensitivity and venom immunotherapy practice in Ankara, Turkey. Materials and methods Data of 65 Hymenoptera venom allergic patients who were followed up in our department from February 2005 to August 2009 were analysed. Immunotherapy was recommended to the patients with...

Bibliography

1. Mueller U. Insect sting allergy. Stuttgart Germany: Gustav Fischer; 1990.
2. Kalyoncu AF, Demir AU, Ozcan U, Ozkuyumcu C, Sahin AA, Bariş YI, et-al. Bee and wasp venom allergy in Turkey. Ann Allergy Asthma Immunol. 1997 Apr; 78:408-12.
Pubmed
3. Kalyoncu AF. The prevalence of Hymenoptera stings and allergy in primary school children in Ankara. Int Rev Allergol Clin Immunol. 1998; 4:136-8.
4. Statistical Data of Ministry of Agriculture, 1995.
5. Moffitt JE, Golden DBK, Reisman RE, Lee R, Nicklas R, Freeman T, et-al. Stinging insect hypersensitivity: a practice parameter update. J Allergy Clin Immunol. 2004; 114:869-86.
Pubmed
6. Bilo BM, Rueff F, Mosbech H, Bonifazi F, Oude-Elberink JN. Diagnosis of Hymenoptera venom allergy. Allergy. 2005; 60:1339-49.
Pubmed
7. Mueller HL. Diagnosis and treatment of insect sensitivity. J Asthma Res. 1966; 3:331-3.
Pubmed
8. Osterballe O, Nielsen JP. A new lancet for skin prick testing. Allergy. 1979; 34:209-12.
Pubmed
9. Müller U, Mosbech H. Position paper: Immunotherapy with Hymenoptera venoms. Allergy Supplement. 1996; 48:37-46.
10. Birnbaum J, Ramadour M, Magnan A, Vervloet D. Hymenoptera ultra-rush venom immunotherapy (210min): a safety study and risk factors. Clin Exp Allergy. 2003 Jan; 33:58-64.
Pubmed
11. Bonifazi F, Jutel M, Bilo BM. Allergy. 2005; 60:1459-70.
Pubmed
12. Volcheck GW. Hymenoptera (Apid and Vespid) allergy: update in diagnosis and management. Current Allergy and Asthma Reports. 2002; 2:46-50.
Pubmed
13. Golden DBK. Insect allergy. Clinical science. Chapter 81:1475–86.
14. Rueff F, Pryzbilla B, Bilo MB, Müller U, Scheipl F, Aberer W, et-al. Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: Importance of baseline serum tryptase-a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity. J Allergy Clin Immunol. 2009; 124:1047-54.
Pubmed
15. Baenkler HW, Meusser-Storm S, Eger G. Continuous immunotherapy for Hymenoptera venom allergy using six month intervals. Allergol et Immunopathol. 2005; 33:7-14.
16. Bjorkander J, Belin L. Diagnostic skin testing in Hymenoptera sensitivity. En: Oehling A., editors. Advances in allergology and applied immunology. New York, USA: Pergamon Pres; 1980. 733.
17. Golden DBK, Kagey-Sobotka A, Norman PS, Hamilton RG, Lichtenstein LM. Insect sting allergy with negative venom skin test responses. J Allergy Clin Immunol. 2001; 107:897-901.
Pubmed
18. Celikel S, Karakaya G, Yurtsever N, Sorkun K, Kalyoncu AF. Bee and bee products allergy in Turkish beekeepers: determination of risk factors for systemic reactions. Allergol Immunopathol (Madr). 2006 Sep-Oct; 34:108-14.
19. Müller UR. Bee venom allergy in beekeepers and their family members. Curr Opin Allergy Clin Immunol. 2005; 5:343-7.
Pubmed
20. Birnbaum J, Vervloet D, Charpin D. Atopy and systemic reactions to Hymenoptera stings. Allergy Proc. 1994; 15:49-52.
Pubmed

Karakaya, Gula; Celebioglu, Ebrua; Demir, A. Ugurb; Kalyoncu, A. Fuata

aDepartment of Chest Diseases, Adult Allergy Unit, Hacettepe University Medical School, Ankara, Turkey

bDepartment of Chest Diseases, Hacettepe University Medical School, Ankara, Turkey