Recommendations for administering the triple viral vaccine and antiinfluenza vaccine in patients with egg allergy

Published in Allergol Immunopathol (Madr). 2007;35:209-12. - vol.35 núm 05

Abstract

En la actualidad, la alergia alimentaria constituye una patología emergente; siendo la alergia al huevo la más frecuente en la infancia. Las recomendaciones para la vacunación de sarampión, parotiditis y rubéola (vacuna triple vírica), así como para la vacuna antigripal, aumentan cada año. El cumplimiento de estas recomendaciones aumenta la exposición de pacientes alérgicos al huevo a dichas vacunas. En España, desde el año 2004 solo se dispone de vacuna triple vírica cultivada en fibroblastos de embrión de pollo; anteriormente, los pacientes alérgicos al huevo se inmunizaban con una vacuna alternativa cultivada en células diploides humanas que no se comercializa actualmente. La vacuna antigripal se cultiva en huevos de gallina y el producto final contiene proteína de huevo (la cantidad en proteína de huevo es muy variable). Dada la existente controversia, el Comité de Alergia Alimentaria de la Sociedad Española de Inmunología Clínica y Alergia Pediátrica ha decidido establecer una serie de recomendaciones para la administración segura de la vacuna triple vírica y la vacuna antigripal en pacientes alérgicos al huevo. En resumen, la vacuna triple vírica es segura para los niños alérgicos al huevo, sólo en los pacientes con reacción anafiláctica grave tras la ingesta de huevo se recomienda su administración en su hospital de referencia. La vacuna antigripal está contraindicada en pacientes con reacción anafiláctica grave tras la ingesta de huevo. El resto pueden vacunarse con una administración fraccionada en 2 dosis y con una vacuna que contenga igual o menos de 1.2 mcg de proteína de huevo por ml
Key words: egg allergy, childhood, MMR vaccination, influenza vaccination.

Introduction

In Spain, the indications for the triple viral vaccine and antiinfluenza vaccine are established by the Vaccines Advisory Committee (VAC) of the Spanish Pediatrics Association. The calendar recommended for this year (2007) establishes a first triple viral vaccine dose at 12-15 months of age, followed by a second dose at 3-4 years of age. The indications for the antiinfluenza vaccine in the pediatric population have increased in recent years. Accordingly, among the recommendations for the campaign 2006-2007, the VAC included antiinfluenza vaccination of children with chronic illnesses, including respiratory disorders and specifically bronchial asthma1. In the United States, the indications of the Advisory Committee on Immunization Practices (ACIP) for this same vaccination campaign moreover included healthy children between 6-59 months of age2. On the other hand, a continuous increase in atopic disorders is being observed, including food allergies, which affect 8 % of the pediatric population. Allergy to egg is the most common food allergy in this age group, and in 79 % of cases the disorder manifests before 5 years of age3. Thus, an increasing number of children with egg allergy are seen in which administration of the triple viral vaccine and antiinfluenza vaccine is indicated. In view of this problem, the Food Allergy Committee of the Spanish Society of Clinical Immunology and Pediatric Allergy ( Sociedad Española de Inmunología Clínica y Alergia Pediátrica , SEICAP) has examined the subject with the purpose of defining a series of recommendations or guidelines. TRIPLE VIRAL VACCINE In Spain, two...

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Piquer-Gibert, Ma; Plaza-Martín, Aa; Martorell-Aragonés, Aa; Ferré-Ybarz, La; Echeverría-Zudaire, La; Boné-Calvo, Ja; Nevot-Falcó, Sa

aFood Allergy Committee of the Sociedad Española de Inmunología Clínica y Alergología Pediátrica (SEICAP).