Prediction of atopy by skin prick tests in patients with asthma and/or persistent rhinitis

Published in Allergol Immunopathol (Madr). 2012;40:37-40. - vol.40 núm 01

Abstract

Background

Patient history gives important clues about the likelihood of atopy. However, the accuracy of assessment of atopy based on detailed allergy history is low. The objective of this survey was to determine the successful prediction rate of atopy by a questionnaire and the effect of various factors on the successful prediction.

Methods

A standard questionnaire including detailed allergy history was filled in by two experienced allergists for 169 patients having bronchial asthma and/or persistent rhinitis symptoms. Skin prick test (SPT) results were predicted based on the clinical data obtained by a questionnaire. Final diagnosis was made after SPT. Sensitivity and specificity analysis of SPT results prediction was investigated using two different cut-off values (3mm and 5mm) for positive tests, and factors associated with successful atopy prediction were analysed.

Results

SPT was predicted to be positive in 42.6% and was positive in 36.1%. Depending on SPT results with the cut-off value 3mm, prediction sensitivity was 77%, specificity was 65.3%, positive predictive value was 65%, and negative predictive value was 86%. Successful positive atopy prediction was associated with age; true negative prediction was also associated with age and high education. With the threshold of 5mm for a positive test, sensitivity, specificity, positive and negative predicted values were 91%, 61%, 14% and 99%, respectively.

Conclusion

It seems that the success rate of detailed history is high for negative prediction. However, detailed history alone does not seem to be efficient for atopy prediction.

Key words: Allergy. Asthma. Atopy. Bronchial asthma. Prediction of atopy. Rhinitis. Skin prick test.

Introduction

Introduction Skin prick test (SPT) is standard for diagnosis of atopy and identifying the sensitisation to specific allergens. In clinical allergy practice, diagnostic management is made by performing SPT, which is a simple and safe procedure.1 However, in general practice, SPT is not used very commonly and allergy diagnosis is usually made by doctors’ opinion. One of the reasons for not integrating SPT into general practice is its cost. Another reason is the need for training and time for performing and interpreting the results of SPT. Although patient history gives important clues about the likelihood of atopy, the accuracy of an assessment of atopy based on detailed allergy history is low.2 There is no standard validated questionnaire for identifying atopic status. Detailed allergy history, including age, gender, age at onset of disease, duration of disease, exacerbating factors, seasonality of symptoms, symptom differences at indoors and outdoors, pet ownership, family history of allergic disease, smoking status, etc. can help to predict patients’ allergic status. Successful prediction is important to distinguish allergic and non-allergic disease correctly and to take the right decisions for the treatment, including allergen avoidance. The aim of this survey was to determine the successful prediction rate of atopy in patients having bronchial asthma (BA) and/or persistent rhinitis (PR) symptoms by a questionnaire based on detailed history and the effect of various factors on the successful prediction. Materials and methods Patients and questionnaire We identified adult patients (16–79 years of age) admitted to our Adult Allergy Unit for the first time with symptoms of...

Bibliography

1. Reid MJ, Lockey RF, Turkeltaub PC, Platts-Mills TA. Survey of fatalities from skin testing and immunotherapy 1985–1989. J Allergy Clin Immunol. 1991; 92:6-15.
Pubmed
2. Smith HE, Hogger C, Lallemant C, Crook D, Frew AJ. Is structured allergy history sufficient when assessing patients with asthma and rhinitis in general practice?. J Allergy Clin Immunol. 2009; 123:646-50.
Pubmed
3. Österballe O, Weeke B. A new lancet for skin prick testing. Allergy. 1979; 34:187-94.
Pubmed
4. Jin Y, Wang W, Xu Y, Zhao J, Liu H, Xue S. Familial aggregation of skin sensitization to aeroallergens in a rural area in China. Int Arch Allergy Immunol. 2009; 148:81-6.
Pubmed
5. Kanthawatana S, Maturim W, Fooanan S, Trakultivakorn M. Skin prick reaction and nasal provocation response in diagnosis of nasal allergy to the house dust mite. Ann Allergy Asthma Immunol. 1997; 79:427-30.
Pubmed
6. Clark AT, Ewan PM. Interpretation of tests for nut allergy in one thousand patients, in relation to allergy or tolerance. Clin Exp Allergy. 2003; 33:1041-5.
Pubmed

Karakaya, G.a; Ozturk, A.B.a; Kalyoncu, A.F.a

aHacettepe University School of Medicine, Department of Chest Diseases, Adult Allergy Unit, Sihhiye, TR-06100 Ankara, Turkey