Effects of physical exercise on lung injury and oxidant stress in children with asthma
Published in Allergol Immunopathol (Madr). 2012;40:20-4. - vol.40 núm 01
Abstract
Background
The aim of this study was to investigate the influence of exercise training on oxidative stress and markers of lung inflammation in children with asthma.
Methods
Thirty children aged 8-13 years diagnosed with asthma were enrolled in the study as well as 13 healthy children. One group received only pharmacological treatment and the other group was also enrolled in an exercise programme. Venous blood and 24-hour urine samples were obtained from the children enrolled in the study at the beginning and end of the study. Leukotriene E4 and creatinine levels were measured in the urine and matrix metallopeptidase (MMP-9), endothelin-1(ET-1), malnodialdehyde (MDA), IgE and specific IgE levels were measured in blood samples.
Results
Leukotriene E4, MDA and MMP9 levels decreased significantly with treatment in both groups (p<0.001). However, ET-1 levels decreased significant only in the exercise group (26.5±3.6 vs 21.3±2.4pg/ml respectively, p=0.001). Moreover, ET-1 levels were found to be significantly lower in the exercise group compared to the only pharmacotherapy group (24.2±3.1 vs 21.3±2.4pg/ml, p=0.007).
Conclusions
Positive influences of exercise training in children with asthma may be mediated by decrease in ET-1 levels.
Key words: Asthma. exercise training. Lung injury. Oxidant stress.
Introduction
Introduction
Children and adults with asthma may avoid exercise because of their respiratory symptoms and they may have reduced exercise tolerance due to the increased sensation of dyspnoea.9, 10, 20 Exercise programmes in asthma have been demonstrated to be associated with improved fitness levels and quality of life as well as a reduction in the need for medications, fewer visits to the emergency department, and decreased absenteeism from school.6, 11, 15, 26, 28 Moreover, physical training was found to increase cardiorespiratory fitness and work capacity in patients with asthma.24 Most of these previous studies have enrolled adult patients but a recent study on children demonstrated that eight weeks of basketball training had beneficial effects on exercise capacity and quality of life.4 However, the results of previous studies about the influence of exercise training on spirometry are contradictory.28 Training may increase exercise capacity without leading to a major change in rest lung function tests.18 The basic pathogenetic mechanisms underlying these changes in asthma with exercise training is unclear.
When oxidative stress overwhelms anti-oxidant mechanisms, reactive oxygen species interact with proteins, lipids and DNA leading to pathological consequences.8 Oxidative stress is thought to initiate airway inflammation; therefore it is an important component of asthma pathogenesis.25 It has been demonstrated that endothelin-1 was associated with oxidative stress in lung diseases like emphysema and that it increased MMP-9 activity leading to destruction of parenchyma.7 Moreover, blockage of ET-1 receptors has been reported to down regulate pulmonary inflammation.7
Therefore, the aim of this study was to investigate the...
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Gunay, Ozlema; Onur, Ecea; Yilmaz, Ozgeb; Dundar, Pinar E.c; Tikiz, Canand; Var, Ahmeta; Yuksel, Hasanb
aCelal Bayar University Medical Faculty, Dept of Biochemistry, Manisa, Turkey
bCelal Bayar University Medical Faculty, Dept of Allergy and Pulmonology, Manisa, Turkey
cCelal Bayar University Medical Faculty, Dept of Public Health, Manisa, Turkey
dCelal Bayar University Medical Faculty, Dept of Physical Medicine and Rehabilitation, Manisa, Turkey
