Pulmonology

ISSN: 2531-0437

Pulmonology (previously Revista Portuguesa de Pneumologia) is the official journal of the Portuguese Society of Pulmonology (Sociedade Portuguesa de Pneumologia/SPP). The journal publishes 6 issues per year, mainly about respiratory system diseases in adults and clinical research. This work can range from peer-reviewed original articles to review articles, editorials, and opinion articles. The journal is printed in English, and is freely available in its web page as well as in Medline and other databases.

Special Issue 2023. Volume 29, Issue S4.

Indexed in:

Science Citation Index Expanded, Journal of Citation Reports; Index Medicus/MEDLINE; Scopus; EMBASE/Excerpta Medica

Abstract
Keywords
Resumo
Palavras chave
Introduction
Materials and methods
Patients and tissue samples
Tissue microarrays building
Analysis of protein expression: immunohistochemistry
Methylation-specific polymerase chain reaction assay for the hmlh1 and hmsh2 genes
Statistical analysis
Results
Protein expression of mlh1 and msh2 in tissue microarrays
Mlh1 and msh2 methylation status in tumour samples
Relationship between the methylation status and ihc protein expression
Discussion
Ethical disclosures
Protection of human and animal subjects
Confidentiality of data
Right to privacy and informed consent
Funding
Conflicts of interest
Bibliography

Original article

DOI: 10.1016/j.rppneu.2013.07.003

Open Access

Promoter hypermethylation of DNA repair genes MLH1 and MSH2 in adenocarcinomas and squamous cell carcinomas of the lung

Hipermetilação Promotora de Genes Reparadores de DNA MLH1 e MSH2 em Adenocarcinomas e Carcinomas de Células Escamosas do Pulmão

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A. Gomesa,b, M. Reis-Silvab,c, A. Alarcãob,c, P. Couceirob,c, V. Sousaa,c, L. Carvalhoa,c,

Corresponding author

lcarvalho@huc.min-saude.pt

Corresponding author.

a Department of Anatomical Pathology, University Hospitals of Coimbra, Portugal

b CIMAGO, Faculty of Medicine, University of Coimbra, Portugal

c Institute of Anatomical Pathology, Faculty of Medicine, University of Coimbra, Portugal

Article

This article is available in English

Promoter hypermethylation of DNA repair genes MLH1 and MSH2 in adenocarcinomas and squamous cell carcinomas of the lung

A. Gomes, M. Reis-Silva, A. Alarcão, P. Couceiro, V. Sousa, L. Carvalho

10.1016/j.rppnen.2013.07.007

Rev Port Pneumol. 2014;20:20-30

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Article

Promoter hypermethylation of DNA repair genes MLH1 and MSH2 in adenocarcinomas and squamous cell carcinomas of the lung

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