Revista Portuguesa de Cardiologia (English edition)

ISSN: 2174-2049

The Portuguese Journal of Cardiology, the official journal of the Portuguese Society of Cardiology, was founded in 1982 with the aim of keeping Portuguese cardiologists informed through the publication of scientific articles on areas such as arrhythmology and electrophysiology, cardiovascular surgery, intensive care, coronary artery disease, cardiovascular imaging, hypertension, heart failure and cardiovascular prevention. The Journal is a monthly publication with high standards of quality in terms of scientific content and production. Since 1999 it has been published in English as well as Portuguese, which has widened its readership abroad. It is distributed to all members of the Portuguese Societies of Cardiology, Internal Medicine, Pneumology and Cardiothoracic Surgery, as well as to leading non-Portuguese cardiologists and to virtually all cardiology societies worldwide. It has been referred in Medline since 1987.

Indexed in:

Index Medicus/Medline, Science Citation Index Expanded/Journal of Citation Reports, Scopus

Abstract
Keywords
Resumo
Introdução e objetivos
Métodos
Resultados
Conclusão
Palavras-chave
Introduction
Methods
Cell culture and treatments
Cell viability assay
Western blot
Chymotrypsin-like activity
Immunoprecipitation
Statistical analysis
Results
Methylglyoxal reduces cell viability in hl-1 cells
Methylglyoxal induces dose-dependent destabilization of hif-1α under hypoxia in hl-1 cells
Methylglyoxal induces ubiquitination of hif-1α in hl-1 cells
Discussion
Conclusion
Ethical disclosures
Protection of human and animal subjects
Confidentiality of data
Right to privacy and informed consent
Conflicts of interest
Acknowledgments
Bibliography

Original Article

DOI: 10.1016/j.repc.2016.09.018

Open Access

Hyperglycemia-induced degradation of HIF-1α contributes to impaired response of cardiomyocytes to hypoxia

A degradação do HIF-1α induzida pela hiperglicemia contribui para a desregulação na resposta à hipoxia pelos cardiomiócitos

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Ana Rita Ramalhoa, Adriana Toscanob, Paulo Pereirab, Henrique Girãob, Lino Gonçalvesa, Carla Marquesb,

Corresponding author

cmarques@fmed.uc.pt

Corresponding author.

a Coimbra Hospital and University Center - Cardiology Department, Coimbra, Portugal

b CNC.IBILI, Institute of Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal

Article

This article is available in English

Hyperglycemia-induced degradation of HIF-1α contributes to impaired response of cardiomyocytes to hypoxia

Ana Rita Ramalho, Adriana Toscano, Paulo Pereira, Henrique Girão, Lino Gonçalves, Carla Marques

10.1016/j.repce.2016.09.015

Rev Port Cardiol. 2017;36:367-73

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Hyperglycemia-induced degradation of HIF-1α contributes to impaired response of cardiomyocytes to hypoxia

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