Journal Information
Vol. 25. Issue 3.
Pages 166-171 (May 2006)
Vol. 25. Issue 3.
Pages 166-171 (May 2006)
DOI: 10.1157/13088412
Función renal relativa basada en captación de ácido dimercaptosuccínico corregida por volumen: función renal relativa normalizada
Relative renal function based on DMSA uptake corrected for volume: normalized relative renalfunction
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Tabla 2. DISTRIBUCION PORCENTUAL DE LOS CASOS ADULTOS SEGUN SU CAPTACION RENAL
Fig. 4. --Distribución porcentual de casos normales y patológicos para el grupo de pacientes infantiles (A) y para el de adultos (B). La barra de la izquierda representa la distribución utilizando la frecuencia renal relativa (FRR). Las demás barras representan la distribución utilizando la frecuencia renal relativa normalizada (FRRN) para diferentes márgenes de normalidad.
Fig. 5. --Distribución porcentual de casos según su variación en el diagnóstico para los grupos de pacientes infantiles (A) y adultos (B). El asterisco se corresponde con los diagnósticos a partir de la frecuencia renal relativa normailzada (FRRN).
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Abstract.--Objective. Relative renal function (RRF) quantification based on dimercaptosuccinic acid (DMSA) uptake is an established method for determining differential renal function. An abnormal kidney size may lead to an alteration in its RRF value, although it has no dysfunction. Therefore, it is useful to correct RRF values taking into account relative renal volumes, thus obtaining the normalized relative renal function (NRRF). The feasibility of the method used for volume correction, differences with respect to usual quantification and different normality intervals were studied. Material and methods. A total of 187 DMSA renal scintigraphies (130 children and 57 adults) were studied. RRF was quantified and volume corrected to obtain NRRF. Patients were classified as normal or pathological using various normality intervals for NRRF. A second classification was performed depending on how the diagnostic changed after volume correction. Results. An increase of pathological diagnosis was observed after volume correction, mainly in children. Using an intermediate estimation for the normality interval, 53 % of the initially pathological diagnosis for children may be caused simply by different renal volumes. Conclusions. NRRF provides complementary information to RRF and helps to distinguish between a smaller kidney and a really hypofunctioning one in cases with abnormal RRF.
Keywords:
renal scintigraphy, 99mTc-DMSA, relative renal function, volume correction
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