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Case report
Leflunomide-induced Stevens Johnson syndrome in a patient with systemic lupus erythematosus
Síndrome de Stevens Johnson inducido por leflunomida en un paciente con lupus eritematoso sistémico
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Diana Nathalie Rincón-Riaño, Daniel G. Fernández-Ávila
Corresponding author
, Juan M. Gutiérrez
Unidad de Reumatología, Hospital Universitario San Ignacio–Pontificia Universidad Javeriana, Bogotá, Colombia
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Received 27 December 2016. Accepted 11 May 2017
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Table 1. Cases of SJS and NET reported in the literature.
Abstract

Leflunomide is an immunomodulatory agent widely used in rheumatoid arthritis and other rheumatic diseases like psoriatic arthritis and systemic lupus erythematosus. Although its safety profile is generally good, side effects have been reported in up to 20% of cases. Severe reactions, such as toxic epidermal necrolysis and Stevens Johnson syndrome are rare. The case is presented of a leflunomide-induced Stevens Johnson syndrome in a patient with systemic lupus erythematosus.

Keywords:
Leflunomide
Stevens–Johnson syndrome
Adverse effects
Resumen

La leflunomida es un agente inmunomodulador de amplio uso en artritis reumatoide y también empleado en otras enfermedades reumáticas como artritis psoriásica y lupus eritematoso sistémico. Aunque su perfil de seguridad en general es bueno, se han reportado reacciones secundarias hasta en un 20%, aunque casos severos como necrólisis epidérmica tóxica y síndrome de Stevens Johnson son de muy baja frecuencia de presentación. Reportamos un caso de síndrome de Stevens Johnson inducido por leflunomida en una paciente con lupus eritematoso sistémico.

Palabras clave:
Leflunomida
Síndrome Stevens Johnson
Efectos adversos

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