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2016 FI

© Thomson Reuters, Journal Citation Reports, 2016

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Current Contents/Clinical Medicine, Journal Citation Reports, SCI-Expanded, Index Medicus/Medline, Excerpta Medica/EMBASE, IBECS, IME, MEDES, PASCAL, SCOPUS, ScienceDirect


  • Impact Factor: 1,125(2016)
  • 5-years Impact Factor: 1,292
  • SCImago Journal Rank (SJR):0,221
  • Source Normalized Impact per Paper (SNIP):0,385

© Thomson Reuters, Journal Citation Reports, 2016

Med Clin 2005;125:761-5 - DOI: 10.1016/S0025-7753(05)72184-9
Valor de la determinación de la proteína C reactiva como marcador pronóstico y de infección en pacientes críticos
Serum C-reactive protein as a marker of outcome and infection in critical care patients
Gemma Seller-Péreza,, , Manuel E. Herrera-Gutiérreza, Miguel Lebrón-Gallardoa, Inmaculada de Toro-Peinadob, Lina Martín-Hitab, José A. Porras-Ballesterosb
a Servicio de Cuidados Críticos y Urgencias. Complejo Hospitalario Carlos Haya. Málaga. España
b Sección de Microbiología. Complejo Hospitalario Carlos Haya. Málaga. España
Received 15 March 2005, Accepted 07 June 2005
Background and objective

C-reactive protein (CRP) has been considered a marker for infection and an aid for diagnosing sepsis. We analyze the relation of CRP to infection and outcome in intensive care units (ICU) patients.

Patients and method

Prospective study on 77 ventilated patients. Expected short ICU stay or (suspected or confirmed) infection at admission were excluding criteria. 55 admissions after elective surgery were the controls. CRP measurement the first (CRP-1), third (CRP-3) and sixth (CRP-6) day of stay. APACHE II (Acute Physiology Score and Chronic Health Evaluation), SOFA (Sepsis-related Organ Failure Assessment), shock, respiratory or renal failure, leucocytes, platelets and albumin were registered. Follow-up until day 9 for infection and ICU discharge for outcome.


CRP-1 in controls was 5.3 (3.9) mg/l and cases 67.8 (77.4) (p<0.001). Shock on admission was related to CRP-1: patients in shock had higher CRP-1 levels (118.6 [82.8] vs 62.8 [75.6]; p=0.06).

40.25% of cases developed infection, and CRP-1 levels were higher in this patients (88.8 [93.9] vs 53.8 [60.9]; p<0.05). ROC area under curve was 0.6 with a sensibility of 23% and a specificity of 89% for a level of CRP-1>100.

Mortality was 23.4% in cases and 1.8% in controls. Age, shock, APACHE II and SOFA were related to mortality, but CRP-1 did not. ROC area under curve for CRP-1 as mortality predictor in all patients was 0.62 (0.76 for APACHE II and 0.77 for SOFA) but only in cases was of 0.49 (0.69 for APACHE II and 0.67 for SOFA).


CRP level on admission is an useful marker for early infection but not for outcome in critically ill patients admited to the ICU.

Palabras clave
Proteína C reactiva, Infección, UCI, Pronóstico
Key words
C-reactive protein, Infection, ICU, Outcome
This article is only available in PDF
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Correspondencia: Dra. G. Seller-Pérez. Complejo Hospitalario Carlos Haya. Avda. Carlos Haya, s/n. 29010 Málaga. España.
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