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Utilidad del índice neutrófilo/linfocito y del índice polimorfonuclear/monomorfonuclear, en la predicción de preeclampsia
Utility of the neutrophil/lymphocyte ratio and the polymorphonuclear/ monomorphonuclear ratio, in the prediction of preeclampsia
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A.M. Ghelfia,
Corresponding author
albertinaghelfi@hotmail.com

Autor para correspondencia.
, M.N. Lassusb, S. Diodatia, E.A. Hailsb
a Servicio de Clínica Médica, Hospital Escuela Eva Perón, Granadero Baigorria, Santa Fe, Argentina
b Servicio de Obstetricia, Hospital Escuela Eva Perón, Granadero Baigorria, Santa Fe, Argentina
This item has received
Received 19 March 2018. Accepted 07 June 2018
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Abstract
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Tables (3)
Tabla 1. Características clínicas basales de los gruposa
Tabla 2. Comparación de medias leucocitarias y de índices celulares, según el desarrollo o no de PE
Tabla 3. Comparación de medias leucocitarias y de índices celulares en pacientes del grupo 1, entre casos de PE en HTA gestacional vs. PE sobreagregada en HTA crónica
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Resumen
Introducción

La aparición de preeclampsia (PE) comprendería alteraciones de la función endotelial y activación de la respuesta inflamatoria, generando hipoperfusión placentaria. El índice neutrófilo/linfocito (INL) y el índice polimorfonuclear/monomorfonuclear (IPM) podrían medir el componente inflamatorio subyacente y predecir la aparición del trastorno.

Material y métodos

Estudio observacional, analítico, de casos y controles. Se analizaron retrospectivamente historias clínicas de embarazadas internadas por registros hipertensivos, divididas en grupo 1=con PE desarrollada y grupo 2=sin PE desarrollada.

Resultados

Se incluyó a 110 pacientes: grupo 1=58,2% y grupo 2=41,8%, observándose diferencias entre las medias del INL (p=0,01) y del IPM (p=0,02). Un INL ≥ 4,5 (p=0,002; OR=3,9; IC del 95%=1,6-9,5) y con un IPM ≥ 3 (p=0,004; OR=3,5; IC del 95%=1,4-8,4) se relacionaron con PE.

Conclusión

La elevación del INL y del IPM en pacientes gestantes hipertensas podría considerarse indicador del desarrollo de PE.

Palabras clave:
Neutrófilo
Linfocito
Índice
Preeclampsia
Abstract
Introduction

The appearance of preeclampsia (PE) would comprise the alteration of endothelial function and activation of the inflammatory response, leading to placental hypoperfusion. The neutrophil/lymphocyte ratio (NLR) and the polymorphonuclear/monomorphonuclear ratio (PMR) could measure the underlying inflammatory component and predict the onset of the disorder.

Material and methods

Observational, analytical, case and control study. We retrospectively analysed medical records of pregnant women, hospitalized for hypertension registers. The patients were divided into Group1=with PE development, and Group2=without PE development.

Results

110 patients were included: Group1=58.2% and Group2=41.8%, observing differences between the NLR means (P=.01) and PMR means (P=.02). An NLR ≥4.5 (P=.002; OR=3.9; 95%CI=1.6-9.5) and a PMR ≥3 (P=.004; OR=3.5; 95%CI=1.4-8.4) was related with PE.

Conclusion

The elevation of NLR and PMR in hypertensive pregnant patients, could be considered indicators for the development of PE.

Keywords:
Neutrophil
Lymphocyte
Ratio
Preeclampsia

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