x

¿Aún no está registrado?

Cree su cuenta. Regístrese en Elsevier y obtendrá: información relevante, máxima actualización y promociones exclusivas.

Registrarme ahora
Help - - Sign up - Phone number 902 888 740
Search

Indexed in:

Index Medicus/MEDLINE, Excerpta Medica/EMBASE, SCOPUS, Science Citation Index Expanded, Journal Citation Reports/Science Edition, IBECS

Metrics

  • Impact Factor: 1,106(2016)
  • SCImago Journal Rank (SJR):0,314
  • Source Normalized Impact per Paper (SNIP):0,383

© Thomson Reuters, Journal Citation Reports, 2016

Endocrinol Nutr 2005;52:556-63 - DOI: 10.1016/S1575-0922(05)71064-0
Revisión
Consumo de café y diabetes mellitus
Coffee consumption and diabetes mellitus
G. Rojo-Martínez??, , S. Morcillo, M.C. Almaraz, F. Soriguer
Servicio de Endocrinología y Nutrición. Hospital Civil. Hospital Universitario Carlos Haya. Málaga. España.
Received 10 January 2005, Accepted 09 May 2005
Abstract

Desde hace muchos años se ha estudiado la relación entre el consumo de café y diversas enfermedades, principalmente cardiovasculares y cáncer, pero también enfermedades psiquiátricas y, más recientemente, relación con la diabetes mellitus.

En este trabajo revisaremos los datos disponibles sobre la relación entre el café y el riesgo de presentar diabetes, con una breve referencia a la relación del café con las enfermedades cardiovasculares.

Los trabajos sobre la relación entre la ingesta de café y la presencia de diabetes son divergentes, ya que, mientras algunos grandes estudios de cohortes parecen indicar un efecto protector sobre la aparición de diabetes mellitus, los estudios de intervención (todos a corto plazo) suelen demostrar un efecto deletéreo sobre el metabolismo glucídico. Las relaciones entre el consumo de café y el riesgo de presentar diabetes mellitus están lejos de establecerse definitivamente. Posiblemente, la relación entre el consumo de café y la salud esté condicionada no solo por la presencia de sustancias bioactivas en el café –que además poseen efectos opuestos sobre el metabolismo glucídico, por ejemplo–, sino también por la forma de preparar la bebida (filtrado, hervido, expreso, instantáneo, natural o torrefacto…) que altera su composición final, y por otro lado por la asociación entre el consumo de café y otros hábitos dietéticos o no (ingesta de alcohol, tabaquismo, actividad física, incluso costumbre de dormir la siesta) que pueden influir de manera directa en los aspectos de la salud en los que también parecen influir los componentes del café.

Abstract

The association between coffee consumption and various diseases, mainly cardiovascular diseases and cancer but also psychiatric disorders and, more recently, diabetes mellitus, has been investigated for many years.

In the present article, we review the evidence available on the association between coffee intake and the risk of diabetes and briefly review the association between coffee intake and cardiovascular disease.

Studies on the association between coffee intake and diabetes report contradictory results; while some large cohort studies seem to indicate a protective effect against the development of diabetes mellitus, intervention studies (all short-term) usually demonstrate a harmful effect on glucose metabolism.

The association between coffee consumption and the risk of diabetes mellitus is far from being definitively established. The relationship between coffee intake and health may be influenced not only by the presence of bioactive substances in coffee (which, moreover, have opposite effects on glucose metabolism, for example) but also by the way the beverage is prepared (filtered, boiled, express, instant, natural or darkroasted…),which affects its final composition. The relationship between coffee consumption and other dietary and health-related factors (alcohol intake, smoking, physical activity, even the habit of taking an afternoon nap) may also be of influence. These factors may have a direct effect on the aspects of health influenced by the components of coffee.

Palabras clave
Café, Cafeína, Diabetes mellitus, Ácido clorogénico, Antioxidantes
Key words
Coffee, Caffeine, Diabetes mellitus, Chlorogenic acid, Antioxidants
This article is only available in PDF
Bibliografía
1.
A. Gutierrez
Café, antioxidantes y protección de la salud
Medisan, 6 (2002), pp. 72-81
2.
K.J. Mukamal,M. Maclure,J.E. Muller,J.B. Sherwood,M.A. Mittleman
Caffeinated coffee consumption and mortality after acute myocardial infarction
Am Heart J, 147 (2004), pp. 999-1004 http://dx.doi.org/10.1016/j.ahj.2003.12.038
3.
C. La Vecchia,B. D’Avanzo,E. Negri,S. Franceschi,A. Gentile,A. Tavani
Decaffeinated coffee and acute myocardial infarction. A case-control study in Italian women
Ann Epidemiol, 3 (1993), pp. 601-604
4.
D.B. Panagiotakos,C. Pitsavos,C. Chrysohoou,P. Kokkinos,P. Toutouzas,C. Stefanadis
The J-shaped effect of coffee consumption on the risk of developing acute coronary syndromes: the CARDIO2000 case-control study
J Nutr, 133 (2003), pp. 3228-3232
5.
L. El-Khairy,P.M. Ueland,O. Nygard,H. Refsum,S.E. Vollset
Lifestyle and cardiovascular disease risk factors as determinants of total cysteine in plasma: the Hordaland Homocysteine Study
Am J Clin Nutr, 70 (1999), pp. 1016-1024
6.
O. Nygard,H. Refsum,P.M. Ueland,I. Stensvold,J.E. Nordrehaug,G. Kvale
Coffee consumption and plasma total homocysteine: The Hordaland Homocysteine Study
Am J Clin Nutr, 65 (1997), pp. 136-143
7.
R. Urgert,A.G. Schulz,M.B. Katan
Effects of cafestol and kahweol from coffee grounds on serum lipids and serum liver enzymes in humans
Am J Clin Nutr, 61 (1995), pp. 149-154
8.
P. Happonen,S. Voutilainen,J.T. Salonen
Coffee drinking is dose-dependently related to the risk of acute coronary events in middle-aged men
J Nutr, 134 (2004), pp. 2381-2386
9.
A. Tavani,M. Bertuzzi,S. Gallus,E. Negri,C. La Vecchia
Risk factors for non-fatal acute myocardial infarction in Italian women
10.
K.J. Mukamal,M. Maclure,J.E. Muller,J.B. Sherwood,M.A. Mittleman
Caffeinated coffee consumption and mortality after acute myocardial infarction
Am Heart J, 147 (2004), pp. 999-1004 http://dx.doi.org/10.1016/j.ahj.2003.12.038
11.
H.D. Sesso,J.M. Gaziano,J.E. Buring,C.H. Hennekens
Coffee and tea intake and the risk of myocardial infarction
Am J Epidemiol, 149 (1999), pp. 162-167
12.
E. Casiglia,P. Mormino,P. Spolaore,O. Maschio,C. Cernetti,F. Costa
Cardiovascular effects of coffee consumption in the aged: the CASTEL epidemiologic study
Cardiologia, 35 (1990), pp. 827-832
13.
R.M. Van Dam,E.J. Feskens
Coffee consumption and risk of type 2 diabetes mellitus
14.
A. Reunanen,M. Heliovaara,K. Aho
Coffee consumption and risk of type 2 diabetes mellitus
15.
A. Saremi,M. Tulloch-Reid,W.C. Knowler
Coffee consumption and the incidence of type 2 diabetes
Diabetes Care, 26 (2003), pp. 2211-2212
16.
E. Salazar-Martínez,W.C. Willett,A. Ascherio,J.E. Manson,M.F. Leitzmann,M.J. Stampfer
Coffee consumption and risk for type 2 diabetes mellitus
Ann Intern Med, 140 (2004), pp. 1-8
17.
J. Tuomilehto,G. Hu,S. Bidel,J. Lindstrom,P. Jousilahti
Coffee consumption and risk of type 2 diabetes mellitus among middle-aged Finnish men and women
18.
S.M. Virtanen,L. Rasanen,A. Aro,K. Ylonen,R. Lounamaa,H.K. Akerblom
Is children's or parents’ coffee or tea consumption associated with the risk for type 1 diabetes mellitus in children? Childhood Diabetes in Finland Study Group
Eur J Clin Nutr, 48 (1994), pp. 279-285
19.
S.H. Jee,J. He,L.J. Appel,P.K. Whelton,I. Suh,M.J. Klag
Coffee consumption and serum lipids: a meta-analysis of randomized controlled clinical trials
Am J Epidemiol, 153 (2001), pp. 353-362
20.
F. Soriguer,G. Rojo-Martínez,I. Esteva
Coffee consumption and type 2 diabetes mellitus
Ann Intern Med, 141 (2004), pp. 321-323
21.
A. Isogawa,M. Noda,Y. Takahashi,T. Kadowaki,S. Tsugane
Coffee consumption and risk of type 2 diabetes mellitus
22.
E.E. Agardh,S. Carlsson,A. Ahlbom,S. Efendic,V. Grill,N. Hammar
Coffee consumption, type 2 diabetes and impaired glucose tolerance in Swedish men and women
J Intern Med, 255 (2004), pp. 645-652 http://dx.doi.org/10.1111/j.1365-2796.2004.01331.x
23.
J. Arnlov,B. Vessby,U. Riserus
Coffee consumption and insulin sensitivity
24.
A. Rosengren,A. Dotevall,L. Wilhelmsen,D. Thelle,S. Johansson
Coffee and incidence of diabetes in Swedish women: a prospective 18-year follow-up study
J Intern Med, 255 (2004), pp. 89-95
25.
D.J. Naismith,P.A. Akinyanju,S. Szanto,J. Yudkin
The effect, in volunteers, of coffee and decaffeinated coffee on blood glucose, insulin, plasma lipids and some factors involved in blood clotting
Nutr Metab, 12 (1970), pp. 144-151
26.
R.M. Van Dam,W.J. Pasman,P. Verhoef
Effects of coffee consumption on fasting blood glucose and insulin concentrations: randomized controlled trials in healthy volunteers
Diabetes Care, 27 (2004), pp. 2990-2992
27.
O.M. Jankelson,S.B. Beaser,F.M. Howard,J. Mayer
Effect of coffee on glucose tolerance and circulating insulin in men with maturity-onset diabetes
Lancet, 1 (1967), pp. 527-529
28.
L.J. Feinberg,H. Sandberg,O. De Castro,S. Bellet
Effects of coffee ingestion on oral glucose tolerance curves in normal human subjects
Metabolism, 17 (1968), pp. 916-922
29.
K.L. Johnston,M.N. Clifford,L.M. Morgan
Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine
Am J Clin Nutr, 78 (2003), pp. 728-733
30.
D.V. Rodríguez de Sotillo,M. Hadley
Chlorogenic acid modifies plasma and liver concentrations of: cholesterol, triacylglycerol, and minerals in (fa/fa) Zucker rats
J Nutr Biochem, 13 (2002), pp. 717-726
31.
H. Hemmerle,H.J. Burger,P. Below,G. Schubert,R. Rippel,P.W. Schindler
Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase
J Med Chem, 40 (1997), pp. 137-145 http://dx.doi.org/10.1021/jm9607360
32.
T. Matsui,S. Ebuchi,K. Fukui,K. Matsugano,N. Terahara,K. Matsumoto
Caffeoylsophorose, a new natural alpha-gluco-si-dase inhibitor, from red vinegar by fermented purple-fleshed sweet potato
Biosci Biotechnol Biochem, 68 (2004), pp. 2239-2246
33.
J. Takaya,H. Higashino,Y. Kobayashi
Intracellular magnesium and insulin resistance
Magnes Res, 17 (2004), pp. 126-136
34.
R. Lopez-Ridaura,W.C. Willett,E.B. Rimm,S. Liu,M.J. Stampfer,J.E. Manson
Magnesium intake and risk of type 2 diabetes in men and women
Diabetes Care, 27 (2004), pp. 134-140
35.
Y. Song,J.E. Manson,J.E. Buring,S. Liu
Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in women
Diabetes Care, 27 (2004), pp. 59-65
36.
F.L. Hsu,Y.C. Chen,J.T. Cheng
Caffeic acid as active principle from the fruit of Xanthium strumarium to lower plasma glucose in diabetic rats
Planta Med, 66 (2000), pp. 228-230 http://dx.doi.org/10.1055/s-2000-8561
37.
P. Nawrot,S. Jordan,J. Eastwood,J. Rotstein,A. Hugenholtz,M. Feeley
Effects of caffeine on human health
Food Addit Contam, 20 (2003), pp. 1-30 http://dx.doi.org/10.1080/0265203021000007840
38.
M.L. Nurminen,L. Niittynen,R. Korpela,H. Vapaatalo
Coffee, caffeine and blood pressure: a critical review
Eur J Clin Nutr, 53 (1999), pp. 831-839
39.
S.H. Jee,J. He,P.K. Whelton,I. Suh,M.J. Klag
The effect of chronic coffee drinking on blood pressure: a meta-analysis of controlled clinical trials
Hypertension, 33 (1999), pp. 647-652
40.
I. Biaggioni,S.N. Davis
Caffeine: a cause of insulin resistance?
Diabetes Care, 25 (2002), pp. 399-400
41.
G.B. Keijzers,B.E. De Galan,C.J. Tack,P. Smits
Caffeine can decrease insulin sensitivity in humans
Diabetes Care, 25 (2002), pp. 364-369
42.
D. Robertson,D. Wade,R. Workman,R.L. Woosley,J.A. Oates
Tolerance to the humoral and hemodynamic effects of caffeine in man
J Clin Invest, 67 (1981), pp. 1111-1117
43.
F. Greer,R. Hudson,R. Ross,T. Graham
Caffeine ingestion decreases glucose disposal during a hyperinsulinemic-euglycemic clamp in sedentary humans
Diabetes, 50 (2001), pp. 2349-2354
44.
T.E. Graham,P. Sathasivam,M. Rowland,N. Marko,F. Greer,D. Battram
Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test
Can J Physiol Pharmacol, 79 (2001), pp. 559-565
45.
F.S. Thong,T.E. Graham
Caffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans
J Appl Physiol, 92 (2002), pp. 2347-2352
46.
L.J. Feinberg,H. Sandberg,O. De Castro,S. Bellet
Effects of coffee ingestion on oral glucose tolerance curves in normal human subjects
Metabolism, 17 (1968), pp. 916-922
47.
J.D. Lane,C.E. Barkauskas,R.S. Surwit,M.N. Feinglos
Caffeine impairs glucose metabolism in type 2 diabetes
Diabetes Care, 27 (2004), pp. 2047-2048
48.
L.E. Robinson,S. Savani,D.S. Battram,D.H. McLaren,P. Sathasivam,T.E. Graham
Caffeine ingestion before an oral glucose tolerance test impairs blood glucose management in men with type 2 diabetes
J Nutr, 134 (2004), pp. 2528-2533
49.
H.J. Petrie,S.E. Chown,L.M. Belfie,A.M. Duncan,D.H. McLaren,J.A. Conquer
Caffeine ingestion increases the insulin response to an oral-glucose-tolerance test in obese men before and after weight loss
Am J Clin Nutr, 80 (2004), pp. 22-28
50.
M. Van Soeren,T. Mohr,M. Kjaer,T.E. Graham
Acute effects of caffeine ingestion at rest in humans with impaired epinephrine responses
J Appl Physiol, 80 (1996), pp. 999-1005
51.
F.S. Thong,T.E. Graham
Caffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans
J Appl Physiol, 92 (2002), pp. 2347-2352
52.
F.S. Thong,W. Derave,B. Kiens,T.E. Graham,B. Urso,J.F. Wojtaszewski
Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise
Diabetes, 51 (2002), pp. 583-590
53.
D.M. Kuftinec,J. Mayer
Extreme sensitivity of obese hyperglycemic mice to caffeine and coffee
Metabolism, 13 (1964), pp. 1369-1375
54.
K. Yoshioka,A. Kogure,T. Yoshida,T. Yoshikawa
Coffee consumption and risk of type 2 diabetes mellitus
Lancet, (2003), pp. 361-703
55.
C.L. Shi
Effects of caffeine and acetylcholine on glucose-stimulated insulin release from islet transplants in mice
Cell Transplant, 6 (1997), pp. 33-37
56.
J.D. Bruton,R. Lemmens,C.L. Shi,S. Persson-Sjogren,H. Westerblad,M. Ahmed
Ryanodine receptors of pancreatic beta-cells mediate a distinct context-dependent signal for insulin secretion
FASEB J, 17 (2003), pp. 301-303 http://dx.doi.org/10.1096/fj.02-0481fje
Correspondencia: Dra. G. Rojo-Martínez. Laboratorio de Investigación. Servicio de Endocrinología y Nutrición. Pabellón 5. Sótano. Hospital Civil. Hospital Universitario Carlos Haya. Pl. Hospital Civil, s/n. 29009 Málaga. España. (G. Rojo-Martínez gemma.rojo.exts@juntadeandalucia.es)
Copyright © 2005. Sociedad Española de Endocrinología y Nutrición