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2017 FI

© Thomson Reuters, Journal Citation Reports, 2017

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  • Impact Factor: 1.644 (2017)
  • CiteScore 2017: 1.24
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  • SCImago Journal Rank (SJR):0,504
  • Source Normalized Impact per Paper (SNIP):0,791

© Clarivate Analytics, Journal Citation Reports 2017

Allergol Immunopathol (Madr) 2018;46:3-8 - DOI: 10.1016/j.aller.2017.02.006
Original Article
Single and multiple food allergies in infants with proctocolitis
B.T. Koksala,, , Z. Barısb, F. Ozcayb, O. Yilmaz Ozbeka
a Department of Pediatrics, Division of Pediatric Allergy, Baskent University Faculty of Medicine, Ankara, Turkey
b Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Baskent University Faculty of Medicine, Ankara, Turkey
Received 27 December 2016, Accepted 18 February 2017

Food protein-induced allergic proctocolitis is a frequent cause of rectal bleeding in infants. Characteristics of infants with multiple food allergies have not been defined.


This study aimed to identify characteristics of infants with proctocolitis and compare infants with single and multiple food allergies.


A total of 132 infants with proctocolitis were evaluated retrospectively. All of the infants were diagnosed by a paediatric allergist and/or a paediatric gastroenterologist according to guidelines. Clinical features of the infants, as well as results of a complete blood count, skin prick test, specific immunoglobulin E, and stool examinations or colonoscopy were recorded.


Cow's milk (97.7%) was the most common allergen, followed by egg (22%). Forty-five (34.1%) infants had allergies to more than one food. Infants with multiple food allergies had a higher eosinophil count (613±631.2 vs. 375±291.9) and a higher frequency of positive specific IgE and/or positive skin prick test results than that of patients with a single food allergy. Most of the patients whose symptoms persisted after two years of age had multiple food allergies.


There is no difference in clinical presentations between infants with single and multiple food allergies. However, infants with multiple food allergies have a high blood total eosinophil count and are more likely to have a positive skin prick test and/or positive specific IgE results.

Allergic proctocolitis, Bloody stool, Colonoscopy, Eosinophil count, Multiple food allergies, Skin prick test, Specific immunoglobulin E
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