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Allergologia et Immunopathologia
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Inicio Allergologia et Immunopathologia Gene polymorphisms of interleukin-10 and transforming growth factor beta in alle...
Journal Information
Vol. 44. Num. 2.March - April 2016
Pages 97-188
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Vol. 44. Num. 2.March - April 2016
Pages 97-188
Original Article
DOI: 10.1016/j.aller.2015.05.010
Gene polymorphisms of interleukin-10 and transforming growth factor beta in allergic rhinitis
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R. Nasiria, A. Hirbod-Mobarakehb,c,d, M. Movahedie, E. Farhadif, B. Ansaripourb,c, A.A. Amirzargarb,c, N. Rezaeib,c,g,
Corresponding author
rezaei_nima@tums.ac.ir

Corresponding author.
a Department of Pediatrics, Kurdistan University of Medical Sciences, Sanandaj, Iran
b Universal Scientific Education and Research Network (USERN), Tehran, Iran
c Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
d Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
e Department of Pediatrics, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
f Hematology Department, School of Allied Medical Science, Iran University of Medical Sciences, Tehran, Iran
g Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
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Tables (4)
Table 1. Clinical characteristics of patients with AR.
Table 2. Allele and genotype frequencies in patients and controls.
Table 3. Haplotype frequencies in patients group and control group.
Table 4. Significant associations between SNP genotypes and clinical findings in patients with AR.
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Abstract
Background

Allergic rhinitis (AR) is a polygenic inflammatory disorder of the upper respiratory airway with an increasing prevalence worldwide. Interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β), as two cytokines with pleiotropic effects on both innate and adaptive immunity, play important roles in allergic responses. Therefore, this study was performed to evaluate the associations of five polymorphisms of IL-10 and TGF-β genes with AR.

Materials and methods

Ninety-eight patients with AR along with 140 healthy volunteers with no history of AR and with the same ethnicity of the patients were recruited in this study. Genotyping was done for three polymorphisms in promoter region of IL-10 gene (rs1800896, rs1800871, rs1800872), and two polymorphisms in the exonic region of TGF-β1 gene (rs1982037, rs1800471) using PCR sequence-specific-primers method.

Results

A allele and AA genotype in rs1800896 of IL-10 and TT genotype in rs1982037 in TGF-β were significantly less frequent in the patients than in controls. While the C allele and the CG genotype in rs1800471 in TGF-β1 were associated with a higher susceptibility to AR. C/C and T/C haplotypes (rs1982037, rs1800471) in TGF-β1 gene and A/C/A, A/T/C and G/C/A haplotypes (rs1800896, rs1800871, rs1800872) in IL-10 gene were found with higher frequencies in patients than controls. Patients with CC genotype in rs1800871 in Il-10 had significantly lower levels of IgE.

Conclusion

We found that certain genetic variants in IL-10 and TGF-β polymorphisms were associated with susceptibility to AR as well as some clinical parameters in the patients with AR.

Keywords:
Allergic rhinitis
Genetic susceptibility
Single nucleotide polymorphism
Interleukin-10
Transforming growth factor beta

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