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2016 FI

© Thomson Reuters, Journal Citation Reports, 2016

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  • Impact Factor: 1.439 (2016)
  • CiteScore 2017: 1.24
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  • SCImago Journal Rank (SJR):0,504
  • Source Normalized Impact per Paper (SNIP):0,791

© Thomson Reuters, Journal Citation Reports, 2017

Allergol Immunopathol (Madr) 2016;44:125-30 - DOI: 10.1016/j.aller.2015.05.010
Original Article
Gene polymorphisms of interleukin-10 and transforming growth factor beta in allergic rhinitis
R. Nasiria, A. Hirbod-Mobarakehb,c,d, M. Movahedie, E. Farhadif, B. Ansaripourb,c, A.A. Amirzargarb,c, N. Rezaeib,c,g,,
a Department of Pediatrics, Kurdistan University of Medical Sciences, Sanandaj, Iran
b Universal Scientific Education and Research Network (USERN), Tehran, Iran
c Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
d Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
e Department of Pediatrics, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
f Hematology Department, School of Allied Medical Science, Iran University of Medical Sciences, Tehran, Iran
g Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
Received 22 January 2015, Accepted 26 May 2015

Allergic rhinitis (AR) is a polygenic inflammatory disorder of the upper respiratory airway with an increasing prevalence worldwide. Interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β), as two cytokines with pleiotropic effects on both innate and adaptive immunity, play important roles in allergic responses. Therefore, this study was performed to evaluate the associations of five polymorphisms of IL-10 and TGF-β genes with AR.

Materials and methods

Ninety-eight patients with AR along with 140 healthy volunteers with no history of AR and with the same ethnicity of the patients were recruited in this study. Genotyping was done for three polymorphisms in promoter region of IL-10 gene (rs1800896, rs1800871, rs1800872), and two polymorphisms in the exonic region of TGF-β1 gene (rs1982037, rs1800471) using PCR sequence-specific-primers method.


A allele and AA genotype in rs1800896 of IL-10 and TT genotype in rs1982037 in TGF-β were significantly less frequent in the patients than in controls. While the C allele and the CG genotype in rs1800471 in TGF-β1 were associated with a higher susceptibility to AR. C/C and T/C haplotypes (rs1982037, rs1800471) in TGF-β1 gene and A/C/A, A/T/C and G/C/A haplotypes (rs1800896, rs1800871, rs1800872) in IL-10 gene were found with higher frequencies in patients than controls. Patients with CC genotype in rs1800871 in Il-10 had significantly lower levels of IgE.


We found that certain genetic variants in IL-10 and TGF-β polymorphisms were associated with susceptibility to AR as well as some clinical parameters in the patients with AR.

Allergic rhinitis, Genetic susceptibility, Single nucleotide polymorphism, Interleukin-10, Transforming growth factor beta
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