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Allergologia et Immunopathologia
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Inicio Allergologia et Immunopathologia Effect of once-daily generic ciclesonide on exhaled nitric oxide in atopic child...
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Vol. 44. Num. 2.March - April 2016
Pages 97-188
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Vol. 44. Num. 2.March - April 2016
Pages 97-188
Original Article
DOI: 10.1016/j.aller.2015.01.011
Effect of once-daily generic ciclesonide on exhaled nitric oxide in atopic children with persistent asthma
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J. Mallola,
Corresponding author
jmallol@vtr.net

Corresponding author.
, V. Aguirrea, A. Gallardoa, E. Corteza, C. Sáncheza, C. Riquelmea, P. Córdovaa, M. Martíneza, A. Galindob
a Department of Paediatric Respiratory Medicine, Hospital CRS El Pino, University of Santiago de Chile (USACH), Chile
b Respiratory Physiotherapist, “El Manzano” Primary Health Care Centre, Santiago, Chile
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Table 1. Mean values (95% CI) at baseline and after 12 weeks of treatment with once-daily CIC (80 or 160μg) in children with persistent asthma.
Abstract
Background

Ciclesonide (CIC) is an effective inhaled corticosteroid for treating asthmatic children. However, its effect on airway inflammation assessed by the fraction of exhaled nitric oxide (FENO) in children with persistent asthma is virtually unknown. We aimed to assess the effect of once-daily generic CIC, 80 or 160μg, on FENO, lung function, asthma control and bronchial hyperresponsiveness, in atopic children with persistent asthma.

Methods

This was a 12-week, randomised, double-blind, parallel-group study. Sixty children with mild-to-moderate persistent asthma were recruited. Changes in FENO, asthma control score, lung function (FEV1) and bronchial hyperresponsiveness to methacholine (BHR) were used to assess the effects of both CIC doses. Non-normally distributed variables were log-transformed to approximate normality, and parametric tests were used for comparisons within and between groups at baseline and after 12 weeks of treatment.

Results

In the CIC 80μg group, FENO decreased from 45.0ppb (95% CI 37.8–53.7) to 32.7ppb (95% CI 21.0–47.3) at the end of study (P=0.021), whereas in the CIC 160μg group, FENO decreased from 47.3ppb (95% CI 40.4–55.3) to 30.5ppb (95% CI 24.1–38.7) (P<0.001). The difference between groups in FENO at the end of study was not significant (P=0.693). There was a significant improvement of asthma control with both CIC doses but there was no significant change in BHR or FEV1 in either group.

Conclusion

Once-daily generic ciclesonide (80μg or 160μg), for 12 weeks, is effective to improve airway inflammation and asthma control in atopic children with persistent asthma.

Keywords:
Airway inflammation
Asthma control
Disease management
Inhaled corticosteroids
FENO
Paediatrics

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