Buscar en
Actas Urológicas Españolas (English Edition)
Toda la web
Inicio Actas Urológicas Españolas (English Edition) Clinical usefulness of random biopsies in diagnosis and treatment of non-muscle ...
Journal Information
Vol. 42. Issue 5.
Pages 285-298 (June 2018)
Share
Share
Download PDF
More article options
Visits
7
Vol. 42. Issue 5.
Pages 285-298 (June 2018)
Review article
Clinical usefulness of random biopsies in diagnosis and treatment of non-muscle invasive bladder cancer: Systematic review and meta-analysis
Utilidad clínica de las biopsias aleatorias en el diagnóstico y tratamiento del tumor vesical no-músculo invasivo: revisión sistemática y metaanálisis
Visits
7
J.D. Subielaa, J. Paloua, C. Esquinasb, J.M. Fernández Gómezc, O. Rodríguez Fabaa,
Corresponding author
orodriguez@fundacio-puigvert.es

Corresponding author.
a Unidad de Uro-Oncología, Servicio de Urología, Fundació Puigvert, Universitat Autònoma de Barcelona, Barcelona, Spain
b Unidad de Estadística, Fundació Puigvert, Universitat Autònoma de Barcelona, Barcelona, Spain
c Servicio de Urología, Hospital Universitario Central de Asturias, Universidad de Oviedo, Oviedo, Spain
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (3)
Show moreShow less
Tables (4)
Table 1. Characteristics of the articles and the population included in the analysis.
Table 2. Distribution of pre-selected sites for biopsy taking.
Table 3. Characteristics of the patients according to the result of the random biopsy.
Table 4. Differences in the incidence of positive biopsies according to the random biopsy collection protocol. Only the results of CIS and frank urothelial carcinoma were considered positive.
Show moreShow less
Abstract
Introduction and objective

This systematic review of the literature has been focused on determining the clinical usefulness of random bladder biopsies (RB) in the diagnosis of carcinoma in situ. A meta-analysis was performed to establish the clinic and pathological factors associated to positive biopsies.

Evidence acquisition

A systematic review was performed using Pubmed/Medline database according to the PRISMA guidelines. Thirty-seven articles were included, recruiting a total of 12,657 patients, 10,975 were submitted to RB.

Evidence synthesis

The overall incidence of positive RB was 21.91%. Significant differences were found in the incidence of positive RB when patients were stratified according to urine cytology result, tumor multiplicity, tumor appearance, stage and grade. The results of the meta-analysis revealed that the presence of positive cytology, tumor multiplicity, non-papillary appearance tumors, stage T1 and histological grades G2 and G3 represent the risk factors to predict abnormalities in RB.

Conclusions

The incidence of positive RB in patients with non-muscle invasive bladder cancer was 21.91%. The maximum usefulness of RB was observed when these are performed in a standardized way. The results of the meta-analysis showed that besides positive cytology and non-papillary appearance tumors, tumor multiplicity and histological grades G2 and G3 represent risk factors associated to positive RB, suggesting that the use of RB might be extensive to the intermediate risk group of the European Organization for Research and Treatment of Cancer (EORTC).

Keywords:
Random bladder biopsies
Carcinoma in situ
Non-muscle invasive bladder cancer
Resumen
Introducción y objetivo

Esta revisión sistemática de la literatura se ha focalizado en determinar la utilidad clínica de las biopsias aleatorias (BA) de vejiga para el diagnóstico de carcinoma in situ. Se realizó un metaanálisis para establecer los factores clinicopatológicos asociados a la positividad de dichas biopsias.

Adquisición de la evidencia

Se realizó una revisión sistemática de la literatura usando la base de datos PubMed/Medline siguiendo los criterios PRISMA. Se incluyeron 37 artículos, reclutando un total de 12.657 pacientes, de los que 10.975 fueron sometidos a BA.

Síntesis de la evidencia

La incidencia global de BA positivas fue del 21,91%. Se encontraron diferencias significativas en la positividad de las BA cuando los pacientes fueron estratificados según resultado de la citología, multiplicidad, aspecto tumoral, estadio y grado. Los resultados del metaanálisis revelaron que la presencia de citología positiva, multiplicidad tumoral, tumores de aspecto no papilar, estadio T1 y grados histológicos G2 y G3 representan factores de riesgo que predicen anormalidades en las BA.

Conclusiones

La incidencia de BA positivas en pacientes con tumor vesical no-músculo invasivo fue del 21,91%. El máximo rendimiento de estas biopsias se evidencia cuando se realizan de manera normativizada. Los resultados del metaanálisis muestran que, además de la citología positiva y el aspecto no papilar, la multiplicidad tumoral y los grados histológicos G2 y G3 representan factores asociados a BA positivas, por lo que el uso de dichas biopsias se puede hacer extensivo al grupo de riesgo intermedio de la European Organization for Research and Treatment of Cancer (EORTC).

Palabras clave:
Biopsias aleatorias de vejiga
Carcinoma in situ
Tumor vesical no-músculo invasivo

Article

These are the options to access the full texts of the publication Actas Urológicas Españolas (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Actas Urológicas Españolas (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

Quizás le interese:
10.1016/j.acuroe.2020.10.016
No mostrar más