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Vol. 69. Issue 5.
Pages 291-296 (September - October 2018)
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Vol. 69. Issue 5.
Pages 291-296 (September - October 2018)
Original article
Otoacoustic Emissions in Children Treated With Gentamicin in a Secondary Hospital
Otoemisiones en los niños tratados con gentamicina de un hospital comarcal
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272
Jose Miguel Sequi Caneta,
Corresponding author
sequi_jos@gva.es

Corresponding author.
, Carlos Miguel Angelats Romeroa, Jose Miguel Sequi Sabatera, Ana Miralles Torresa, Miguel Boronat Garciab, Marta Gomez Delgadoa
a Servicio de Pediatría, Hospital Francesc de Borja, Gandia, Valencia, Spain
b Servicio de Laboratorio, Hospital Francesc de Borja, Gandia, Valencia, Spain
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Tables (3)
Table 1. Risk Markers Recommended by CODEPEH 2012.
Table 2. Characteristics of Children Included in the Study.
Table 3. Characteristics of Treatment Used and Creatinine Anaemia Levels.
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Abstract
Introduction

The National Commission for the Early Detection of Hearing Loss (CODEPEH) recommends the re-evaluation of hearing in children who have suffered any potentially harmful event, such as the prescription of ototoxic antibiotics such as gentamicin. The evoked otoacoustic emissions (EOAE) are a good method for assessing the integrity of cochlear functionality.

Material and method

A prospective study is presented, including 92 children who were treated with intravenous gentamicin for septic risk/sepsis or urinary tract infection. The children underwent serial EOAE: on admission, at the end of treatment and one month later (if altered on discharge).

Results

In the end, none of the subjects were affected by the treatment.

Conclusion

Gentamicin appears to be a safe antibiotic in treatments lasting <10 days and at the doses described. EOAE are an inexpensive, fast, non-invasive and reliable method to check for gentamicin ototoxicity. This could save in the determination of drug levels.

Keywords:
Hearing loss
Gentamicin
Ototoxicity
Otoacoustic emissions
Resumen
Introducción

Las recomendaciones de la Comisión Nacional para la Detección Precoz de la Hipoacusia (CODEPEH) aconsejan re-valorar la audición de aquellos niños que hayan sufrido algún evento potencialmente dañino para la audición como es la utilización de antibióticos ototóxicos como la gentamicina. Las otoemisiones evocadas son un buen método de evaluación de la integridad de la función coclear.

Material y método

Se presenta un estudio prospectivo que incluye a 92 niños, sin otros factores de riesgo auditivo, en los que se pautó tratamiento con gentamicina intravenosa por riesgo séptico/sepsis o infección urinaria y en los que se realizaron otoemisiones seriadas: al ingreso, al finalizar el tratamiento y al mes del alta (si estaban alteradas).

Resultados

Ningún sujeto presentó otoemisiones alteradas al final del seguimiento.

Conclusión

La gentamicina parece un antibiótico seguro en tratamientos con una duración <10 días y a las dosis descritas. Las otoemisiones son un método barato, rápido, incruento y fiable para comprobar la posible ototoxicidad por gentamicina. Su realización podría ahorrar la determinación de niveles del fármaco.

Palabras clave:
Sordera
Gentamicina
Ototoxicidad
Otoemisiones acústicas

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